ReviewInternational journal of molecular sciences2022
Mast Cells in the Mammalian Testis and Epididymis-Animal Models and Detection Methods.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Does Heat-Induced Activation of Mast Cells Contribute to Elevated Temperature-Induced Male Infertility?Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Localisation of immune cell populations during human fetal testicular development.Reproduction & fertility · 2026Article
- Interaction Between Telocytes and Mast Cells in Genetically Determined Non-Obstructive Azoospermia with AZFc Deletion: An Ultrastructural Study.International journal of molecular sciences · 2026Article
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- Long-term testicular changes caused by the temporary suspension of puberty initiated at different stages of development.Frontiers in cell and developmental biology · 2026Article
- Gradual Thickening of the Peritubular Lamina Propria in Healthy Boar Seminiferous Tubules Due to Cryptorchidism: Increased Immunoexpression of Diverse Proteins in Sertoli and Myoid Cells.Animals : an open access journal from MDPI · 2025Article
- Mast Cells as a Component of Spermatogonial Stem Cells' Microenvironment.International journal of molecular sciences · 2024Review
- On Connective Tissue Mast Cells as Protectors of Life, Reproduction, and Progeny.International journal of molecular sciences · 2024Review
- Mast Cells: When the Best Defense Is an Attack?International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Mast cells (MCs) are an evolutionary well-conserved type of cells, mediating and modulating allergic responses in innate immunity and tissue remodeling after chronic inflammation. Among other tissues, they inhabit both the testis and epididymis. In the testis, MCs usually appear in the interstitial compartment in humans, but not in other standard experimental models, like rats and mice. MCs seem to be responsible for testicular tissue fibrosis in different causes of infertility. Although experimental animal models follow the effect on MC activation or penetration to the interstitial tissue like in humans to some extent, there is an inconsistency in the available literature regarding experimental design, animal strain, and detection methods used. This comprehensive review offers an insight into the literature on MCs in mammalian testes and epididymides. We aimed to find the most suitable model for research on MC and offer recommendations for future experimental designs. When using in vivo animal models, tunica albuginea incorporation and standard histological assessment need to be included. Domesticated boar strains kept in modified controlled conditions exhibit the highest similarity to the MC distribution in the human testis. 3D testicular models are promising but need further fine-tuning to become a valid model for MC investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.