ArticleInternational journal of molecular sciences2022
Application of a Screen-Printed Sensor Modified with Carbon Nanofibers for the Voltammetric Analysis of an Anticancer Disubstituted Fused Triazinone.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- A Polydopamine-Based Molecularly Imprinted Electrochemical Sensor for Fentanyl Determination.ACS omega · 2025Article
- Thermal Investigations of Annelated Triazinones-Potential Analgesic and Anticancer Agents.Molecules (Basel, Switzerland) · 2023Article
- Combined Micellar Liquid Chromatography Technique and QSARs Modeling in Predicting the Blood-Brain Barrier Permeation of Heterocyclic Drug-like Compounds.International journal of molecular sciences · 2022Article
- Electrochemically Pretreated Sensor Based on Screen-Printed Carbon Modified with Pb Nanoparticles for Determination of Testosterone.Materials (Basel, Switzerland) · 2022Article
- Screen-Printed Voltammetric Sensors-Tools for Environmental Water Monitoring of Painkillers.Sensors (Basel, Switzerland) · 2022Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we propose the first analytical procedure-using a screen-printed carbon electrode modified with carbon nanofibers (SPCE/CNFs)-for the detection and quantitative determination of an electroactive disubstituted fused triazinone, namely 4-Cl-PIMT, which is a promising anticancer drug candidate. The electrochemical performances of the sensor were investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square-wave adsorptive stripping voltammetry (SWAdSV). The presence of carbon nanofibers on the sensor surface caused a decrease in charge-transfer resistance and an increase in the active surface compared to the bare SPCE. Under the optimised experimental conditions, the proposed voltammetric procedure possesses a good linear response for the determination of 4-Cl-PIMT in the two linear ranges of 0.5-10 nM and 10-100 nM. The low limits of detection and quantification were calculated at 0.099 and 0.33 nM, respectively. In addition, the sensor displays high reproducibility and repeatability, as well as good selectivity. The selectivity was improved through the use of a flow system and a short accumulation time. The SWAdSV procedure with SPCE/CNFs was applied to determine 4-Cl-PIMT in human serum samples. The SWAdSV results were compared to those obtained by the ultra-high-performance liquid chromatography coupled with electrospray ionization/single-quadrupole mass spectrometry (UHPLC-ESI-MS) method.
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