Evidence map›Paper›PMID 35269564›Full record

ReviewInternational journal of molecular sciences2022

COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19.

Michele Costanzo, Marianna Caterino, Roberta Fedele, Armando Cevenini, Mariarca Pontillo, Lucia Barra, Margherita Ruoppolo

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Dissecting inflammation in the immunemetabolomic era.Cellular and molecular life sciences : CMLS · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Immunometabolic chaos in septic shock.Journal of leukocyte biology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. The Impact of Serum/Plasma Proteomics on SARS-CoV-2 Diagnosis and Prognosis.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michele CostanzoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-6386-2009
Marianna CaterinoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0001-6035-8213
Roberta FedeleCEINGE-Biotecnologie Avanzate s.c.ar.l., 80145 Naples, Italy.ORCID 0000-0002-2024-9781
Armando CeveniniDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-1858-2833
Mariarca PontilloCEINGE-Biotecnologie Avanzate s.c.ar.l., 80145 Naples, Italy.
Lucia BarraCEINGE-Biotecnologie Avanzate s.c.ar.l., 80145 Naples, Italy.
Margherita RuoppoloDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-7364-0602

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Omics-based technologies have been largely adopted during this unprecedented global COVID-19 pandemic, allowing the scientific community to perform research on a large scale to understand the pathobiology of the SARS-CoV-2 infection and its replication into human cells. The application of omics techniques has been addressed to every level of application, from the detection of mutations, methods of diagnosis or monitoring, drug target discovery, and vaccine generation, to the basic definition of the pathophysiological processes and the biochemical mechanisms behind the infection and spread of SARS-CoV-2. Thus, the term COVIDomics wants to include those efforts provided by omics-scale investigations with application to the current COVID-19 research. This review summarizes the diverse pieces of knowledge acquired with the application of COVIDomics techniques, with the main focus on proteomics and metabolomics studies, in order to capture a common signature in terms of proteins, metabolites, and pathways dysregulated in COVID-19 disease. Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic.

Indexed as

Chromatography, LiquidCOVID-19Host-Pathogen InteractionsHumansMetabolomicsPandemicsProteomeProteomicsSARS-CoV-2Tandem Mass SpectrometryProteomeCOVID-19COVID-19 signatureCOVIDomicsdata integrationdisease progressionmetabolomicsmultiomicspandemicproteomicsSARS-CoV-2

Identifiers

PMID35269564
PMCPMC8910221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.