Evidence map›Paper›PMID 35269477›Full record

ArticleCells2022

RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with

Olga Alexandra Sidorova, Shady Sayed, Maciej Paszkowski-Rogacz, Michael Seifert, Aylin Camgöz, Ingo Roeder, Martin Bornhäuser, Christian Thiede, Frank Buchholz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Olga Alexandra SidorovaMedical Systems Biology, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Shady SayedMedical Systems Biology, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-3209-238X
Maciej Paszkowski-RogaczMedical Systems Biology, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-8245-6006
Michael SeifertInstitute for Medical Informatics and Biometry (IMB), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-2844-053X
Aylin CamgözHopp Children's Cancer Center Heidelberg, 69120 Heidelberg, Germany.
Ingo RoederInstitute for Medical Informatics and Biometry (IMB), Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-6741-0608
Martin BornhäuserGerman Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Christian ThiedeGerman Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0003-1241-2048
Frank BuchholzMedical Systems Biology, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-4577-3344
German Cancer Research Center · DETechnische Universität Dresden · DEZimmer Biomet (Germany) · DE

Funding

German Cancer Aid 70111969
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA Methyltransferase 3ALeukemia, Myeloid, AcuteAdultCell Cycle ProteinsDNA (Cytosine-5-)-MethyltransferasesHumansMutationProto-Oncogene ProteinsRNA InterferenceCell Cycle ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AMDM4 protein, humanProto-Oncogene Proteinsacute myeloid leukemiaDNMT3Afunctional screenMDM4RNAi

Identifiers

PMID35269477
PMCPMC8909053
OpenAlexW4214876363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.