Evidence map›Paper›PMID 35269209›Full record

ArticleMaterials (Basel, Switzerland)2022

Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential.

Kuo-Sheng Hung, May-Show Chen, Wen-Chien Lan, Yung-Chieh Cho, Takashi Saito, Bai-Hung Huang, Hsin-Yu Tsai, Chia-Chien Hsieh, Keng-Liang Ou, Hung-Yang Lin

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Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kuo-Sheng HungGraduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei 110, Taiwan.
May-Show ChenSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Wen-Chien LanDepartment of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, Taiwan.ORCID 0000-0002-2727-1172
Yung-Chieh ChoSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Takashi SaitoDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari 061-0293, Japan.ORCID 0000-0001-8816-7187
Bai-Hung HuangBiomedical Technology R & D Center, China Medical University, Taichung 404, Taiwan.
Hsin-Yu TsaiDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Ishikari 061-0293, Japan.
Chia-Chien HsiehGraduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.
Keng-Liang OuBiomedical Technology R & D Center, China Medical University, Taichung 404, Taiwan.ORCID 0000-0003-1786-6305
Hung-Yang LinDepartment of Dentistry, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City 242, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we proposed a three-dimensional (3D) printed porous (termed as 3DPP) scaffold composed of bioceramic (beta-tricalcium phosphate (β-TCP)) and thermoreversible biopolymer (pluronic F-127 (PF127)) that may provide bone tissue ingrowth and loading support for bone defect treatment. The investigated scaffolds were printed in three different ranges of pore sizes for comparison (3DPP-1: 150−200 μm, 3DPP-2: 250−300 μm, and 3DPP-3: 300−350 μm). The material properties and biocompatibility of the 3DPP scaffolds were characterized using scanning electron microscopy, X-ray diffractometry, contact angle goniometry, compression testing, and cell viability assay. In addition, micro-computed tomography was applied to investigate bone regeneration behavior of the 3DPP scaffolds in the mini-pig model. Analytical results showed that the 3DPP scaffolds exhibited well-defined porosity, excellent microstructural interconnectivity, and acceptable wettability (θ < 90°). Among all groups, the 3DPP-1 possessed a significantly highest compressive force 273 ± 20.8 Kgf (* p < 0.05). In vitro experiment results also revealed good cell viability and cell attachment behavior in all 3DPP scaffolds. Furthermore, the 3DPP-3 scaffold showed a significantly higher percentage of bone formation volume than the 3DPP-1 scaffold at week 8 (* p < 0.05) and week 12 (* p < 0.05). Hence, the 3DPP scaffold composed of β-TCP and F-127 is a promising candidate to promote bone tissue ingrowth into the porous scaffold with decent biocompatibility. This scaffold particularly fabricated with a pore size of around 350 μm (i.e., 3DPP-3 scaffold) can provide proper loading support and promote bone regeneration in bone defects when applied in dental and orthopedic fields.

Indexed as

3D printingbiocompatibilitybone regenerationpluronic F127tricalcium phosphate

Identifiers

PMID35269209
PMCPMC8911960

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.