Evidence map›Paper›PMID 35269205›Full record

ArticleMaterials (Basel, Switzerland)2022

Promiscuous Lipase-Catalyzed Markovnikov Addition of H-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives.

Paweł Kowalczyk, Dominik Koszelewski, Barbara Gawdzik, Jan Samsonowicz-Górski, Karol Kramkowski, Aleksandra Wypych, Rafał Lizut, Ryszard Ostaszewski

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Synthesis and Antimicrobial Activity of the PathogenicInternational journal of molecular sciences · 2023
    Article
  6. Aluminium(III) Oxide-The Silent Killer of Bacteria.Molecules (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Paweł KowalczykDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.ORCID 0000-0003-4025-3750
Dominik KoszelewskiInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0003-0968-3330
Barbara GawdzikInstitute of Chemistry, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Jan Samsonowicz-GórskiInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-5433-4837
Karol KramkowskiDepartment of Physical Chemistry, Medical University of Bialystok, Kilińskiego 1 Str., 15-089 Białystok, Poland.
Aleksandra WypychCentre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, Torun ul. Wileńska 4, 87-100 Toruń, Poland.ORCID 0000-0002-0555-8690
Rafał LizutInstitute of Mathematics, Informatics and Landscape Architecture, The John Paul II Catholic University of Lublin, ul. Konstantynów 1 H, 20-708 Lublin, Poland.ORCID 0000-0002-6067-1469
Ryszard OstaszewskiInstitute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland.ORCID 0000-0002-3032-196X
Institute of Organic Chemistry · PLJan Kochanowski University · PLJohn Paul II Catholic University of Lublin · PLKielanowski Institute of Animal Physiology and Nutrition · PLMedical University of Białystok · PLNicolaus Copernicus University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An enzymatic route for phosphorous-carbon- bond formation is developed by discovering new promiscuous activity of lipase. This biocatalytic transformation of phosphorous-carbon- bond addition leads to biologically and pharmacologically relevant α-acyloxy phosphonates with methyl group in α-position. A series of target compounds were synthesized with yields ranging from 54% to 83% by enzymatic reaction with

Indexed as

enzymatic Markovnikov additionFpg protein-formamidopyrimidineHIV-human immunodeficiency viruslipase promiscuitylipopolysaccharide (LPS)α-acyloxy phosphonates

Identifiers

PMID35269205
PMCPMC8912074
OpenAlexW4220910776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.