Evidence map›Paper›PMID 35268995›Full record

ArticleMaterials (Basel, Switzerland)2022

Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency.

Muhammad Qamar, Ghulam Abbas, Muhammad Afzaal, Muhammad Y Naz, Abdul Ghuffar, Muhammad Irfan, Stanislaw Legutko, Jerzy Jozwik, Magdalena Zawada-Michalowska, Abdulnour Ali Jazem Ghanim and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. One-Dimensional MnMaterials (Basel, Switzerland) · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Muhammad QamarDepartment of Physics, Riphah International University Faisalabad Campus, Faisalabad 44000, Pakistan.ORCID 0000-0002-0926-3400
Ghulam AbbasDepartment of Physics, Riphah International University Faisalabad Campus, Faisalabad 44000, Pakistan.
Muhammad AfzaalDepartment of Physics, Riphah International University Faisalabad Campus, Faisalabad 44000, Pakistan.
Muhammad Y NazDepartment of Physics, University of Agriculture Faisalabad, Faisalabad 38040, Pakistan.
Abdul GhuffarDepartment of Physics, Riphah International University Faisalabad Campus, Faisalabad 44000, Pakistan.
Muhammad IrfanElectrical Engineering Department, College of Engineering, Najran University Saudi Arabia, Najran 11001, Saudi Arabia.ORCID 0000-0003-4161-6875
Stanislaw LegutkoFaculty of Mechanical Engineering, Poznan University of Technology, 60-965 Poznan, Poland.ORCID 0000-0001-8973-5035
Jerzy JozwikFaculty of Mechanical Engineering, Lublin University of Technology, 20-618 Lublin, Poland.ORCID 0000-0002-8845-0764
Magdalena Zawada-MichalowskaFaculty of Mechanical Engineering, Lublin University of Technology, 20-618 Lublin, Poland.ORCID 0000-0003-3330-6340
Abdulnour Ali Jazem GhanimCivil Engineering Department, College of Engineering, Najran University Saudi Arabia, Najran 61441, Saudi Arabia.ORCID 0000-0002-4020-9402
Saifur RahmanElectrical Engineering Department, College of Engineering, Najran University Saudi Arabia, Najran 11001, Saudi Arabia.ORCID 0000-0002-7262-183X
Usama M NiaziDepartment of Mechanical Engineering Technology, National Skills University Islamabad, Islamabad 44000, Pakistan.ORCID 0000-0003-3164-7731
Mohammed JalalahElectrical Engineering Department, College of Engineering, Najran University Saudi Arabia, Najran 11001, Saudi Arabia.ORCID 0000-0002-6828-3874
Fahad Salem AlkahtaniElectrical Engineering Department, College of Engineering, Najran University Saudi Arabia, Najran 11001, Saudi Arabia.
Mohammad K A KhanMechanical Engineering Department, College of Engineering, Najran University Saudi Arabia, Najran 11001, Saudi Arabia.
Ewelina KosickaFaculty of Mechanical Engineering, Lublin University of Technology, 20-618 Lublin, Poland.ORCID 0000-0001-5143-5184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optical properties and electric field enhancement of gold nanorods for different cases were investigated in this study. The numerical analysis was carried out to understand the functionality and working of gold nanorods, while the experimental portion of the work was focused on the efficiency of gold nanorods for targeted drug delivery. COMSOL Multiphysics was used for numerical analysis. The theoretical results suggest the use of gold nanorods (AuNRs) for anticancer applications. The resonance peaks for gold nanorods of 10 nm diameter were observed at 560 nm. The resonance peaks shifted towards longer wavelengths with an increase in nanorod size. The resonance peaks showed a shift of 140 nm with a change in nanorod length from 25 to 45 nm. On the experimental side, 22 nm, 35 nm and 47 nm long gold nanorods were produced using the seed-mediated growth method. The surface morphology of the nanorods, as well as their optical characteristics, were characterized. Later, gold nanorods were applied to the targeted delivery of the doxorubicin drug. Gold nanorods showed better efficiency for doxorubicin drug loading time, release time, loading temperature, and release temperature. These results reveal that AuNRs@DA possess good ability to load and deliver the drug directly to the tumorous cells since these cells show high temperature and acidity.

Indexed as

COMSOL Multiphysicsdoxorubicindrug deliverygold nanorods

Identifiers

PMID35268995
PMCPMC8911263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.