ArticleMolecules (Basel, Switzerland)2022
Exploring Peptaibol's Profile, Antifungal, and Antitumor Activity of Emericellipsin A of
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Whole Genome Sequencing, Comparative Genome Analysis, and Biotechnological Potential ofJournal of fungi (Basel, Switzerland) · 2026Article
- Functional characteristics and distribution of microorganisms in saline and alkaline soils and their probiotic effects: a review.Microbial cell factories · 2026Review
- A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols.Marine drugs · 2025Review
- Endophytic Fungi Isolated from the Marine MacroalgaMycobiology · 2025Article
- Marine-Fungus-Derived Natural Compound 4-Hydroxyphenylacetic Acid Induces Autophagy to Exert Antithrombotic Effects in Zebrafish.Marine drugs · 2024Article
- Haloalkalitolerant Fungi from Sediments of the Big Tambukan Saline Lake (Northern Caucasus): Diversity and Antimicrobial Potential.Microorganisms · 2023Article
- The Cytotoxic Properties of Extreme Fungi's Bioactive Components-An Updated Metabolic and Omics Overview.Life (Basel, Switzerland) · 2023Review
- Isolation and Characterization of a Novel Hydrophobin, Sa-HFB1, with Antifungal Activity from an Alkaliphilic Fungus,Journal of fungi (Basel, Switzerland) · 2022Article
- Marine fungi showing multifunctional activity against human pathogenic microbes and cancer.PloS one · 2022Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Features of the biochemical adaptations of alkaliphilic fungi to exist in extreme environments could promote the production of active antibiotic compounds with the potential to control microorganisms, causing infections associated with health care. Thirty-eight alkaliphilic and alkalitolerant Emericellopsis strains (E. alkalina, E. cf. maritima, E. cf. terricola, Emericellopsis sp.) isolated from different saline soda soils and belonging to marine, terrestrial, and soda soil ecological clades were investigated for emericellipsin A (EmiA) biosynthesis, an antifungal peptaibol previously described for Emericellopsis alkalina. The analysis of the Emericellopsis sp. strains belonging to marine and terrestrial clades from chloride soils revealed another novel form with a mass of 1032.7 Da, defined by MALDI-TOF Ms/Ms spectrometers, as the EmiA lacked a hydroxyl (dEmiA). EmiA displayed strong inhibitory effects on cell proliferation and viability of HCT 116 cells in a dose- and time-dependent manners and induced apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.