Evidence map›Paper›PMID 35268832›Full record

ArticleMolecules (Basel, Switzerland)2022

Efficacy and Limitations of Chemically Diverse Small-Molecule Enzyme-Inhibitors against the Synergistic Coagulotoxic Activities of

Nicholas J Youngman, Matthew R Lewin, Rebecca Carter, Arno Naude, Bryan G Fry

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nicholas J YoungmanVenom Evolution Lab, School of Biological Science, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-4729-5518
Matthew R LewinCalifornia Academy of Sciences, San Francisco, CA 94118, USA.ORCID 0000-0003-4480-9891
Rebecca CarterOphirex Inc., Corte Madera, CA 94925, USA.
Arno NaudeSnakebite Assist, Pretoria ZA-0001, South Africa.
Bryan G FryVenom Evolution Lab, School of Biological Science, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-6661-1283
The University of Queensland · AUCalifornia Academy of Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Snakebite remains a significant public health burden globally, disproportionately affecting low-income and impoverished regions of the world. Recently, researchers have begun to focus on the use of small-molecule inhibitors as potential candidates for the neutralisation of key snake venom toxins and as potential field therapies.

Indexed as

Blood CoagulationViper VenomsAcetatesAnimalsAnticoagulantsEnzyme InhibitorsHumansHydroxamic AcidsIndolesKeto AcidsOrganic ChemicalsPhospholipases A2Snake BitesViperidaeAcetatesAnticoagulantsEnzyme InhibitorsHydroxamic AcidsIndolesKeto AcidsmarimastatOrganic ChemicalsPhospholipases A2prinomastatvarespladibViper VenomsanticoagulantBitismarimastatPLA2prinomastatvarespladibvenom

Identifiers

PMID35268832
PMCPMC8911647
OpenAlexW4221111634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.