Evidence map›Paper›PMID 35268788›Full record

ArticleMolecules (Basel, Switzerland)2022

Expanding the Study of the Cytotoxicity of Incomptines A and B against Leukemia Cells.

Fernando Calzada, Normand Garcia-Hernandez, Sergio Hidalgo-Figueroa, Elihú Bautista, Elizabeth Barbosa, Claudia Velázquez, Marta Elena Hernández-Caballero

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Fernando CalzadaUnidad de Investigación Médica en Farmacología, Unidad Médica de Alta Especialidad, Hospital de Especialidades-2° Piso CORSE Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Ciudad de México 06725, Mexico.ORCID 0000-0003-1851-5988
Normand Garcia-HernandezUnidad de Investigación Médica en Genética Humana, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Ciudad de México 06725, Mexico.ORCID 0000-0001-6021-8309
Sergio Hidalgo-FigueroaCONACyT-Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, Lomas 4ª Sección, San Luis Potosí 78216, Mexico.ORCID 0000-0002-4344-642X
Elihú BautistaCONACyT-Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, Lomas 4ª Sección, San Luis Potosí 78216, Mexico.ORCID 0000-0002-7050-9182
Elizabeth BarbosaSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón esq. Plan de San Luis S/N, Miguel Hidalgo, Casco de Santo Tomas, Ciudad de México 11340, Mexico.ORCID 0000-0002-7111-7922
Claudia VelázquezÁrea Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Km 4.5, Carretera Pachuca-Tulancingo, Unidad Universitaria, Pachuca 42076, Mexico.
Marta Elena Hernández-CaballeroFacultad de Medicina, Biomedicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico.ORCID 0000-0003-4174-2118
Institute for Scientific and Technological Research · MXMexican Social Security Institute · MXBenemérita Universidad Autónoma de Puebla · MXInstituto Politécnico Nacional · MXUniversidad Autónoma del Estado de Hidalgo · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heliangolide-type sesquiterpene lactones (HTSLs) are phytocompounds with several pharmacological activities including cytotoxic and antitumor activity. Both bioactivities are related to an α-methylene-γ-lactone moiety and an ester group on carbon C-8 in the sesquiterpene lactone (SL) structure. Two HTSLs, incomptines A (

Indexed as

LeukemiaMolecular Docking SimulationSesquiterpenesAntineoplastic AgentsAntineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalHL-60 CellsHumansLactonesMolecular StructureAntineoplastic AgentsAntineoplastic Agents, PhytogenicLactonesSesquiterpenescytotoxic activitydockinghuman cancer cell linesincomptine Aincomptine Bleukemiasesquiterpene lactones

Identifiers

PMID35268788
PMCPMC8911839
OpenAlexW4220924077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.