Evidence map›Paper›PMID 35268784›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis of Mono-Amino Substituted γ-CD: Host-Guest Complexation and In Vitro Cytotoxicity Investigation.

Fadwa Odeh, Fedaa Adaileh, Walhan Alshaer, Hamdi Nsairat, Dana A Alqudah, Areej M Jaber, Abeer Al Bawab

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fadwa OdehDepartment of Chemistry, School of Science, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0002-9341-2359
Fedaa AdailehDepartment of Chemistry, School of Science, The University of Jordan, Amman 11942, Jordan.
Walhan AlshaerCell Therapy Center, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0003-2946-7328
Hamdi NsairatPharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.ORCID 0000-0001-5916-5879
Dana A AlqudahCell Therapy Center, The University of Jordan, Amman 11942, Jordan.
Areej M JaberPharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
Abeer Al BawabDepartment of Chemistry, School of Science, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0003-2131-1791
University of Jordan · JOAl-Ahliyya Amman University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclodextrins (CDs) are cyclic oligosaccharides which can trap hydrophobic molecules and improve their chemical, physical, and biological properties. γ-CD showed the highest aqueous solubility with the largest cavity diameter among other CD types. The current study describes a direct and easy method for nucleophilic mono-aminos to be substituted with γ-CD and tested for their ability to host the guest curcumin (CUR) as a hydrophobic drug model. The mass spectrometry and NMR analyses showed the successful synthesis of three amino-modified γ-CDs: mono-6-amino-6-deoxy-cyclodextrine (γ-CD-NH

Indexed as

Curcumingamma-CyclodextrinsCell SurvivalCyclodextrinsFibroblastsHumansHydrophobic and Hydrophilic InteractionsSolubilityCurcuminCyclodextrinsgamma-cyclodextringamma-Cyclodextrinscurcumincyclodextrinsdrug carrierhost–guest complexesmono-amino substitutionweak base modificationγ-CDs

Identifiers

PMID35268784
PMCPMC8911948
OpenAlexW4220657430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.