ArticleMolecules (Basel, Switzerland)2022
Low-Molecular-Weight Secondary Metabolites from Fungi:
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
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- Is laccase from medicinal mushroom Cerrena unicolor cytotoxic to colon cancer cell line CT-26?PloS one · 2025Article
- A complex metabolic network and its biomarkers regulate laccase production in white-rot fungus Cerrena unicolor 87613.Microbial cell factories · 2024Article
- Synthesis and anthelmintic activity of novel thiosemicarbazide and 1,2,4-triazole derivatives: In vitro, in vivo, and in silico study.Journal of advanced research · 2024Article
- Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity inMicrobiology spectrum · 2024Article
- Anthelminthic and antimicrobial effects of hedge woundwort (Frontiers in pharmacology · 2024Article
- Article
- Biologically active secondary metabolites from white-rot fungi.Frontiers in chemistry · 2024Review
- Impact of Agro-Industrial Side-Streams on Sesquiterpene Production by Submerged CulturedFoods (Basel, Switzerland) · 2023Article
- Chemical screening identifies the anticancer properties ofJournal of Cancer · 2023Article
- Chemical screening identifies the anticancer properties ofJournal of Cancer · 2023Article
- Evaluation of Anthelmintic and Anti-Inflammatory Activity of 1,2,4-Triazole Derivatives.Molecules (Basel, Switzerland) · 2022Article
- Discovery of Cinnamylidene Derivative of Rhodanine with High Anthelmintic Activity againstMolecules (Basel, Switzerland) · 2022Article
- Mushrooms as future generation healthy foods.Frontiers in nutrition · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants and fungi are known as a valuable source of natural medicines used in the treatment of various diseases. Many of them are used to treat human and animal gastrointestinal diseases caused by parasites. The aim of this study was to investigate for the first time the antinematode properties of extracellular low-molecular subfractions (ex-LMS) obtained from the liquid growth medium of idiophasic Cerrena unicolor cultures. The fungal fractions were isolated according to a procedure previously described by Jaszek et al. The in vitro tests were performed using nematodes of the Rhabditis genus. As demonstrated by the results, the total fraction with a molecular weight < 10 kDa (CU-A) and the 0.02−1.5 kDa fraction (CU-B) had nematicidal activity. It was found that the analyzed substances induced movement disturbances caused by the paralysis of the back part of the nematode’s body. The degree of body paralysis was proportional to the increase in the concentration of the tested fractions. Summarizing the obtained results in the context of the available literature data, it seems that C. unicolor may be a good new candidate for research on nematode infections.
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