ArticleMolecules (Basel, Switzerland)2022
Changes in Whey Proteome between Mediterranean and Murrah Buffalo Colostrum and Mature Milk Reflect Their Pharmaceutical and Medicinal Value.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Peptidomic Profiling Analysis of Endogenous Peptides in Buffalo Milk During Lactation Stages.Foods (Basel, Switzerland) · 2026Article
- Proteomic analysis of Buffalo milk somatic cells reveals metabolomic and immunological transitions during early lactation.Scientific reports · 2025Article
- Is it advisable for Asians to drink milk, especially those at risk of osteoporosis?Frontiers in nutrition · 2025Review
- Bioactive Peptides in Greek Goat Colostrum: Relevance to Human Metabolism.Foods (Basel, Switzerland) · 2024Article
- Optimizing workflow efficiency for analyzing low molecular weight endogenous peptides in colostrum.RSC advances · 2024Article
- Novel insights into whey protein among Yak, Yellow Cattle, and Cattle-Yak milk.Food chemistry: X · 2024Article
- Strategies and Mechanisms of Thermal Compensation in Newborn Water Buffaloes.Animals : an open access journal from MDPI · 2023Review
- Identification of Protein Quality Markers in Toad Venom fromMolecules (Basel, Switzerland) · 2023Article
- Evaluation of Parity Effect on Characteristics and Minerals in Buffalo (Bubalus Bubalis) Colostrum and Mature Milk.Foods (Basel, Switzerland) · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
Milk represents an integrated meal for newborns; its whey protein is rich in many health beneficial components and proteins. The current study aimed to investigate the differences between colostrum and mature milk from Mediterranean and Murrah buffaloes using labeled proteomics and bioinformatics tools. In the current work, LC-MS/MS analysis led to identification of 780 proteins from which 638 were shared among three independent TMT experiments. The significantly changed proteins between the studied types were analyzed using gene ontology enrichment and KEGG pathways, and their interactions were generated using STRING database. Results indicated that immunological, muscular development and function, blood coagulation, heme related, neuronal, translation, metabolic process, and binding proteins were the main terms. Overall, colostrum showed higher levels of immunoglobulins, myosins, actin, neurofascin, syntaxins, thyroglobulins, and RNA-binding proteins, reflecting its importance in the development and activity of immunological, muscular, cardiac, neuronal, and thyroid systems, while lactoferrin and ferritin were increased in mature milk, highlighting its role in iron storage and hemoglobin formation.
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Registered trials
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