Functionalization of Rhodamine Platforms with 3-Hydroxy-4-pyridinone Chelating Units and Its Fluorescence Behavior towards Fe(III).

Carla Queirós, Sílvia Vinhas, Jéssica Oliveira, Andreia Leite, Ana M G Silva, Maria Rangel

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 61% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Carla QueirósLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal.ORCID 0000-0003-0485-8023

Sílvia VinhasLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal.

Jéssica OliveiraLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal.

Andreia LeiteLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal.ORCID 0000-0002-1967-8853

Ana M G SilvaLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal.ORCID 0000-0003-0393-1655

Maria RangelLAQV/REQUIMTE, Instituto de Ciências Biomédicas de Abel Salazar, 4099-003 Porto, Portugal.ORCID 0000-0002-0998-1437

Universidade do Porto · PT

Funding

FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência), under the Partnership Agreement PT2020 NORTE-07-0162-FEDER-000048FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência), under the Partnership Agreement PT2020 UIDB /50006/2020FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência), under the Partnership Agreement PT2020 UIDP/50006/2020Fundação para a Ciência e Tecnologia EXPL/QUI-OUT/1554/2021Fundação para a Ciência e Tecnologia PTDC/QUI-QIN/28142/2017Fundação para a Ciência e Tecnologia PTDC/QUI-QOR/29426/2017

6 · The paper itself

Abstract

Functionalization of xanthene fluorophores with specific receptor units is an important topic of research aiming for the development of new analytical tools for biological sciences, clinical diagnosis, food and environmental monitoring. Herein, we report a new dihydrorosamine containing two active amino groups, which was functionalized with 3-benzyloxy-1-(3'-carboxypropyl)-2-methyl-4-pyridinone through an amide coupling strategy. Benzylated mono- and di-functionalized dihydrorosamine derivatives (H in position 9 of the xanthene) were obtained, but with modest reaction yields, requiring long and laborious purification procedures. Looking for a more efficient approach, rhodamine 110 was selected to react with the carboxypropyl pyridinone, enabling the isolation of the corresponding mono- and di-functionalized derivatives in amounts that depend on the excess of pyridinone added to the reaction. The structure of all compounds was established by

Indexed as

amide couplingdihydrorosaminefluorescenceoptical propertiespyridinone unitsrhodamine 110

Identifiers

PMID35268668

DOI10.3390/molecules27051567

PMCPMC8911962

OpenAlexW4214674973

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.