Evidence map›Paper›PMID 35268651›Full record

ReviewMolecules (Basel, Switzerland)2022

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications.

Wen-Chin Ko, Su-Jane Wang, Chien-Yu Hsiao, Chen-Ting Hung, Yu-Jou Hsu, Der-Chen Chang, Chi-Feng Hung

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Wen-Chin KoSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Su-Jane WangSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0002-4675-0259
Chien-Yu HsiaoDepartment of Nutrition and Health Science, Chang Guang University of Science and Technology, Taoyuan 33303, Taiwan.
Chen-Ting HungGraduate Institute and Department of Pharmacology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.
Yu-Jou HsuPhD Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Der-Chen ChangDepartment of Mathematics and Statistics and Department of Computer Science, Georgetown University, Washington, DC 20057, USA.
Chi-Feng HungSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0003-3478-5451
Fu Jen Catholic University · TWChang Gung University of Science and Technology · TW

Funding

Cathay General Hospital 110-CGH-FJU-04Ministry of Science and Technology MOST110-2320-B-030-004-MY3
6 · The paper itself

Abstract

Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

Indexed as

GoldMetal NanoparticlesAnimalsAnti-Inflammatory AgentsAntioxidantsHumansNeoplasmsAnti-Inflammatory AgentsAntioxidantsGoldanti-angiogenesisanti-inflammationantioxidantcancergold nanoparticlesnanogold

Identifiers

PMID35268651
PMCPMC8911979
OpenAlexW4214727251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.