Evidence map›Paper›PMID 35268614›Full record

ArticleMolecules (Basel, Switzerland)2022

Influence of Storage Conditions on the Stability of Gum Arabic and Tragacanth.

Paweł Ramos, Mateusz Broncel

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paweł RamosDepartment of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland.ORCID 0000-0003-0030-6002
Mateusz BroncelDepartment of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland.
Medical University of Silesia · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Storage conditions should be chosen so that they do not affect the action and stability of the active pharmaceutical substance (API), and excipients used in pharmacy. UV irradiation, increased temperature, and relative humidity can decompose storage substances by photolysis, thermolysis, and hydrolysis process, respectively. The effect of physical factors may be the decomposition of pharmaceutical substances or their inappropriate action, including pharmacological effects. Polymers of natural origin are increasingly used in the pharmaceutical industry. With this in mind, we evaluated the effect of storage conditions on the stability of gum arabic (GA) and tragacanth (GT). The influence of higher temperature, UV irradiation, and relative humidity on GA and GT was tested. Thermogravimetry (TG, c-DTA), colorimetric analysis, UV-Vis spectrophotometry, and optical microscopy were used as research methods. The TGA and c-DTA examination indicated that decomposition of GA starts at a higher temperature compared to GT. This indicate that gum arabic is more resistant to higher temperatures compared to tragacanth. However, the conducted analysis showed that gum arabic is more sensitive to the tested storage conditions. Among the tested physical conditions, both polymers were most sensitive to conditions of increased relative humidity in the environment.

Indexed as

Drug StabilityGum ArabicHumidityTragacanthDrug StorageTemperatureThermogravimetryUltraviolet RaysGum ArabicTragacanthc-DTAcolorimetric analysisgum arabichigher temperatureoptical microscope observationsproper storage conditionsrelative humidityTGAtragacanthUV-irradiationUV spectrophotometry

Identifiers

PMID35268614
PMCPMC8911758
OpenAlexW4213458285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.