Evidence map›Paper›PMID 35268552›Full record

ArticleJournal of clinical medicine2022

The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction.

Fu-Chun Chiu, Chin-Feng Tsai, Pang-Shuo Huang, Ching-Yu Shih, Mong-Hsun Tsai, Juey-Jen Hwang, Yi-Chih Wang, Eric Y Chuang, Chia-Ti Tsai, Sheng-Nan Chang

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  14. Microbiota: Not Just a Gut Feeling.Journal of clinical medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fu-Chun ChiuDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, Taiwan.
Chin-Feng TsaiDivision of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City 402, Taiwan.ORCID 0000-0003-4475-9708
Pang-Shuo HuangDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, Taiwan.
Ching-Yu ShihBioinformatics & Biostatistics Core Lab, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei City 100, Taiwan.
Mong-Hsun TsaiBioinformatics & Biostatistics Core Lab, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei City 100, Taiwan.
Juey-Jen HwangDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, Taiwan.
Yi-Chih WangDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City 100, Taiwan.
Eric Y ChuangGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City 100, Taiwan.
Chia-Ti TsaiDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City 100, Taiwan.
Sheng-Nan ChangDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, Taiwan.ORCID 0000-0002-2663-5042
National Taiwan University Hospital · TWNational Taiwan University · TWChung Shan Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3−V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (p-value = 0.01 and <0.001 with 95% CI, individually). The Selenomonadales were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of Selenomonadales and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI.

Indexed as

acute coronary syndromemicrobiotamyocardial infarctionseleno-compoundSelenomonadales

Identifiers

PMID35268552
PMCPMC8911090
OpenAlexW4220887656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.