Evidence map›Paper›PMID 35268494›Full record

ArticleJournal of clinical medicine2022

Raman Spectroscopic Study of Amyloid Deposits in Gelatinous Drop-like Corneal Dystrophy.

Giuseppe Acri, Antonio Micali, Rosalia D'Angelo, Domenico Puzzolo, Pasquale Aragona, Barbara Testagrossa, Emanuela Aragona, Edward Wylegala, Anna Nowinska

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Giuseppe AcriDepartment of Biomedical Sciences, Section of Physics, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-8897-2853
Antonio MicaliDepartment of Adult and Pediatric Pathology, University of Messina, 98125 Messina, Italy.
Rosalia D'AngeloDepartment of Biomedical Sciences, Section of Biology and Genetics, University of Messina, 98125 Messina, Italy.
Domenico PuzzoloDepartment of Biomedical Sciences, Section of Histology and Embryology, University of Messina, 98125 Messina, Italy.
Pasquale AragonaDepartment of Biomedical Sciences, Eye Clinic, Regional Referral Center for the Ocular Surface Diseases, University of Messina, 98125 Messina, Italy.ORCID 0000-0002-9582-9799
Barbara TestagrossaDepartment of Biomedical Sciences, Section of Physics, University of Messina, 98125 Messina, Italy.
Emanuela AragonaDepartment of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, 20132 Milan, Italy.
Edward WylegalaChair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-555 Katowice, Poland.ORCID 0000-0002-6707-5790
Anna NowinskaChair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-555 Katowice, Poland.ORCID 0000-0002-8418-3486
University of Messina · ITInstytut Kolejnictwa · PLMedical University of Silesia · PLVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic and histopathological features of the cornea of a Polish patient with Gelatinous Drop-like Corneal Dystrophy (GDCD) and the molecular composition with Raman spectroscopy of corneal deposits were examined. A 62 year-old Polish woman was diagnosed with GDCD and underwent penetrating corneal transplant. A blood sample was collected, and genetic analysis was performed. The cornea was processed for light microscopy and Raman analysis. The genetic exam revealed a previously undescribed homozygous 1-base pair deletion in exon 1 of

Indexed as

amyloid depositscorneagelatinous drop-like corneal dystrophylight microscopyRaman spectroscopyTACSTD2 gene mutation

Identifiers

PMID35268494
PMCPMC8911144
OpenAlexW4220877771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.