ReviewJournal of clinical medicine2022
Congenital Zika Syndrome: Genetic Avenues for Diagnosis and Therapy, Possible Management and Long-Term Outcomes.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Congenital Zika Syndrome and Disabilities of Feeding and Breastfeeding in Early Childhood: A Systematic Review.Viruses · 2023Pooled it
- Pediatric Arboviral Infections in Europe: Epidemiology, Clinical Features, Diagnosis and Prevention.Viruses · 2026Review
- Narrative Nursing and Perioperative Psychological Outcomes in Women Undergoing Cervical Cerclage: The Potential Indirect Role of Fear of Childbirth.The journal of obstetrics and gynaecology research · 2026Article
- Concomitant cytomegalovirus DNAemia is associated with sustained TNF-α elevation in HIV/AIDS: a multivariable and longitudinal analysis of immune restoration.BMC infectious diseases · 2026Observational
- Sex-Stratified Machine Learning for the Prediction of Post-COVID Condition: A Longitudinal Cohort Study.Journal of clinical medicine · 2026Article
- Clinical Presentation and Treatment of Hyperemesis Gravidarum in a Lady Carrying Twins in the First Trimester: A Case Reports.Clinical case reports · 2026Article
- Prenatal Ultrasound Diagnosis of Binder Phenotype: Case Series of Seven Patients and Literature Review.Reports (MDPI) · 2025Article
- Immunohistochemical Analysis of Placental Tissue of Women Infected with SARS-CoV-2 During Pregnancy-A Prospective Clinical Study.International journal of molecular sciences · 2025Article
- Inflammatory Indices and Preterm Delivery: A New Horizon in Obstetric Risk Assessment.Diagnostics (Basel, Switzerland) · 2025Article
- Long-Term Effects of COVID-19 on Women's Reproductive Health and Its Association with Autoimmune Diseases, Including Multiple Sclerosis.Journal of clinical medicine · 2025Review
- The Role of the Genital Tract Microbiome in Human Fertility: A Literature Review.Journal of clinical medicine · 2025Review
- Expression of Estrogen Receptors in Main Immune Organs in Sheep During Early Pregnancy.International journal of molecular sciences · 2025Article
- SARS-CoV-2 Infection and Its Association with Maternal and Fetal Redox Status and Outcomes: A Prospective Clinical Study.Journal of clinical medicine · 2025Article
- Decoding the Puzzle of Male Infertility: The Role of Infection, Inflammation, and Autoimmunity.Diagnostics (Basel, Switzerland) · 2025Review
- Preterm Birth and SARS-CoV-2: Does a Correlation Exist?Biomedicines · 2025Review
- Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture.Open medicine (Warsaw, Poland) · 2025Article
- Predicting Intensive Care Unit Admission in COVID-19-Infected Pregnant Women Using Machine Learning.Journal of clinical medicine · 2024Article
- Prenatal Attachment, Personality, and Depression in High-Risk Pregnancies During Pandemic Emergencies.Healthcare (Basel, Switzerland) · 2024Article
- Vitamin D Receptor-Interplay in COVID-19-Negative, -Infected, and -Vaccinated Women during Pregnancy.Journal of clinical medicine · 2024Article
- Shedding Light on the COVID-19 Pandemic: Placental Expression of Cell Biomarkers in Negative, Vaccinated, and Positive Pregnant Women.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zika virus (ZIKV) was discovered in Uganda in 1947 and was originally isolated only in Africa and Asia. After a spike of microcephaly cases in Brazil, research has closely focused on different aspects of congenital ZIKV infection. In this review, we evaluated many aspects of the disease in order to build its natural history, with a focus on the long-term clinical and neuro-radiological outcomes in children. The authors have conducted a wide-ranging search spanning the 2012-2021 period from databases PubMed, PubMed Central, Web of Science, Medline, Scopus. Different sections reflect different points of congenital ZIKV infection syndrome: pathogenesis, prenatal diagnosis, clinical signs, neuroimaging and long-term developmental outcomes. It emerged that pathogenesis has not been fully clarified and that the clinical signs are not only limited to microcephaly. Given the current absence of treatments, we proposed schemes to optimize diagnostic protocols in endemic countries. It is essential to know the key aspects of this disease to guarantee early diagnosis, even in less severe cases, and an adequate management of the main chronic problems. Considering the relatively recent discovery of this congenital infectious syndrome, further studies and updated long-term follow-up are needed to further improve management strategies for this disease.
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