Evidence map›Paper›PMID 35268335›Full record

ReviewJournal of clinical medicine2022

Obstructive Sleep Apnea and Atrial Fibrillation.

Amalia Ioanna Moula, Iris Parrini, Cecilia Tetta, Fabiana Lucà, Gianmarco Parise, Carmelo Massimiliano Rao, Emanuela Mauro, Orlando Parise, Francesco Matteucci, Michele Massimo Gulizia and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Amalia Ioanna MoulaCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-1547-4095
Iris ParriniCardiology Department, Mauriziano Umberto I Hospital, 10128 Torino, Italy.
Cecilia TettaCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.ORCID 0000-0001-6428-5592
Fabiana LucàCardiology Department, Big Metropolitan Hospital, 89129 Reggio Calabria, Italy.ORCID 0000-0002-5369-5382
Gianmarco PariseCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.
Carmelo Massimiliano RaoCardiology Department, Mauriziano Umberto I Hospital, 10128 Torino, Italy.
Emanuela MauroCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.
Orlando PariseCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-5422-4187
Francesco MatteucciCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-2550-8404
Michele Massimo GuliziaCardiology Department, Garibaldi Nesima Hospital, 95122 Catania, Italy.
Mark La MeirCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-6261-5110
Sandro GelsominoCardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-7746-989X
Maastricht University Medical Centre · NLOspedale Garibaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common arrhythmia, increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a chronic sleep disorder more common in older men. It has been shown that OSA is linked to AF. Nonetheless, the prevalence of OSA in patients with AF remains unknown because OSA is significantly underdiagnosed. This review, including 54,271 patients, carried out a meta-analysis to investigate the association between OSA and AF. We also performed a meta-regression to explore cofactors influencing this correlation. A strong link was found between these two disorders. The incidence of AF is 88% higher in patients with OSA. Age and hypertension independently strengthened this association, indicating that OSA treatment could help reduce AF recurrence. Further research is needed to confirm these findings. Atrial Fibrillation (AF) is the most common arrhythmia, increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a regulatory respiratory disorder of partial or complete collapse of the upper airways during sleep leading to recurrent pauses in breathing. OSA is more common in older men. Evidence exists that OSA is linked to AF. Nonetheless, the prevalence of OSA in patients with AF remains unknown because OSA is underdiagnosed. In order to investigate the incidence of AF in OSA patients, we carried out a meta-analysis including 20 scientific studies with a total of 54,271 subjects. AF was present in 4801 patients of whom 2203 (45.9%) had OSA and 2598 (54.1%) did not. Of a total of 21,074 patients with OSA, 2203 (10.5%) had AF and 18,871 (89.5%) did not. The incidence of AF was 88% higher in patients with OSA. We performed a meta-regression to explore interacting factors potentially influencing the occurrence of AF in OSA. Older age and hypertension independently strengthened this association. The clinical significance of our results is that patients with OSA should be referred early to the cardiologist. Further research is needed for the definition of the mechanisms of association between AF and OSA.

Indexed as

arrhythmiaatrial fibrillationobstructive sleep apnea

Identifiers

PMID35268335
PMCPMC8911205
OpenAlexW4214707080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.