ReviewJournal of clinical medicine2022
Current Concepts in the Etiology and Pathogenesis of Pectus Excavatum in Humans-A Systematic Review.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Thoracoscopic versus non-thoracoscopic repair of pectus excavatum in children: a systematic review and meta-analysis.Journal of cardiothoracic surgery · 2026Pooled it
- A percutaneous sternal elevation technique using the Tian-Ping sternal lifter for Nuss repair of pectus excavatum.Journal of thoracic disease · 2026Article
- Performance of ChatGPT-4o, Gemini 2.0 Pro, and DeepSeek-V3 in Patient-Facing Information on Chest Wall Deformities: A Comparative Evaluation of Accuracy, RELIABILITY, and Reproducibility.Diagnostics (Basel, Switzerland) · 2026Article
- Psychological Impact of Congenital Chest Wall Deformities Among Adolescents and Young Adults.Children (Basel, Switzerland) · 2026Review
- Syncope in a Patient with Right Ventricular Compression from Severe Pectus Excavatum: A Case Report.Clinical practice and cases in emergency medicine · 2026Article
- Genetic Associations with Pectus Excavatum: A Systematic Review.Current issues in molecular biology · 2026Review
- Design of a Patient-Specific 3D-Printed Splint for Surgical Correction of Pectus Excavatum in a Kitten.Case reports in veterinary medicine · 2026Article
- An overview of pectus deformities and rehabilitation approaches.Turkish journal of physical medicine and rehabilitation · 2025Review
- To screen or not to screen: the importance of early detection of pectus excavatum.Translational pediatrics · 2025Article
- Effects of NUSS surgery on degree of flat thoracic cage, cardiopulmonary function, and bone metabolism in pectus excavatum patients of different ages.Updates in surgery · 2025Article
- Article
- Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Complexity of Familial Inheritance in Pectus Excavatum: A Ten-Family Exome Sequencing Analysis.Genes · 2024Article
- Early-Onset Pectus Excavatum Is More Likely to Be Part of a Genetic Variation.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2024Observational
- Spinal posture, mobility, and position sense in adolescents with chest wall deformities: a comparison of pectus excavatum, pectus carinatum and healthy peers.Pediatric surgery international · 2024Article
- Presence of manubrium-sternum joint does not assure sufficient elevation of sternum in Nuss procedure for pectus excavatum patients.General thoracic and cardiovascular surgery · 2024Article
- Post-operative arrest following pectus excavatum repair: A case report with a systematic review of the published case reports.Clinical case reports · 2024Article
- Pectus excavatum and carinatum: a narrative review of epidemiology, etiopathogenesis, clinical features, and classification.Journal of thoracic disease · 2024Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pectus excavatum (PE) is the most common deformity of the chest wall and is characterized by the posterior depression of the sternum and the lower costal cartilages. To date, the etiology of PE in humans remains enigmatic. Several etiologic hypotheses have been proposed over the past two centuries. However, most of them have been scientifically dismissed and now have only historic value. In this systematic review, we assess scientific publications of the past two centuries addressing the issue of the origin of PE in humans. We present and discuss the histologic, genetic, biomechanical, and experimental scientific achievements that contributed to the clarification of its etiology and pathogenesis. With no clear consensus over the exact mechanism, most recent studies agree that the primordial defect leading the deformation of the anterior chest wall in PE is related to the costal hyaline cartilage structure and function. Further studies on this subject must be carried out. Genetic studies seem to be the most promising way to understand the exact mechanism of PE's origin and pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.