ArticleJournal of clinical medicine2022
Serum Hypoalbuminemia Is a Long-Term Prognostic Marker in Medical Hospitalized Patients, Irrespective of the Underlying Disease.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- The C-Reactive Protein/Albumin Ratio Predicts In-Hospital Mortality Across Age Groups.Nutrients · 2026Article
- Predictive Value of the ALBI Grade for Short-Term Morbidity and Mortality After Pancreatoduodenectomy.Cancers · 2026Article
- Protein losing enteropathy and hypoalbuminemia after cardiac surgery.Journal of cardiothoracic surgery · 2026Article
- Combined Association of the Fibrinogen-to-Albumin Ratio and the Uric Acid-to-Albumin Ratio with Mortality in Critically Ill Patients with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Impact of Inflammation and Muscle Mass on Prognosis in Hospitalized Patients with Suspected Dysphagia at a Tertiary Hospital.Geriatrics (Basel, Switzerland) · 2026Article
- Hypoalbuminemia as a predictor of mortality in patients with acute cholangitis: A systematic review and meta-analysis.World journal of gastrointestinal pathophysiology · 2026Article
- Article
- Pandemic and post-pandemic shifts in onset and severity of pediatric nephrotic syndrome: a comparative cohort analysis.Frontiers in immunology · 2026Article
- Risk factors and predictive nomogram of human serum albumin infusion after total hip arthroplasty for femoral head necrosis.European journal of medical research · 2025Article
- Article
- Article
- C-Reactive Protein to Albumin Ratio Predicts Early Mortality in Hospitalized Older Patients, Independent of the Admission Diagnosis.Nutrients · 2025Observational
- Article
- Comprehensive biomarker profiles in hematological malignancies: improving diagnosis, prognosis, and treatment.Biomarkers in medicine · 2025Review
- Hypoalbuminaemia and heart failure: A practical review of current evidence.European journal of heart failure · 2025Review
- Hypoalbuminemia and Postoperative Outcomes Following Major Salivary Gland Resection.Laryngoscope investigative otolaryngology · 2025Article
- Association between red cell distribution width to albumin ratio and clinical outcomes in elderly patients with sepsis: a cohort study.Frontiers in nutrition · 2025Article
- Serum albumin and gamma gap levels, and combined effect for risk of mortality in a Japanese population from the J-MICC study.PloS one · 2025Article
- Microbiota-friendly diet ameliorates hypoalbuminemia in chronic kidney disease: evidence from NHANES.Frontiers in immunology · 2025Article
- Significance of the geriatric nutritional risk index and body composition as prognostic indicators in gastric cancer patients.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoalbuminemia is common in hypoalbuminemia-associated disorders (HAD), e.g., liver and kidney disease. We hypothesize that hospitalized patients with hypoalbuminemia have poor prognosis irrespective of their underlying disease. Records of patients admitted to Medicine (2010−2018), with and without HAD were analyzed, comparing low (<35 g/L) to normal serum albumin. Mann−Whitney and Chi-squared tests were used, and a logistic regression model was applied. Patients: 14,640 were admitted; 9759 were analyzed (2278 hypoalbuminemia: 736 HAD, 1542 non-HAD). All patients, and the subgroups with (as expected) and without HAD had worse outcomes. Specifically, in patients without HAD, those with hypoalbuminemia (n = 1542) vs. normal albumin (n = 6216) were older, had a higher Charlson Comorbidity Index (CCI, 5 vs. 4), longer median hospital stay (5 vs. 4), higher one year re-admission rate (49.9% vs. 39.8%), and one year mortality (48.9% vs. 15.3%, p < 0.001 for all). LR model predicting 3 month, 1 year and 5 year mortality confirmed the predictive power of albumin (1 year: OR = 4.49 for hypoalbuminema, p < 0.01). Hypoalbuminemia portends poor long-term prognosis in hospitalized patients regardless of the underlying disease and could be added to prognostic predictive models.
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