ArticleJournal of clinical medicine2022
Hemorrhagic Transformation in Acute Ischemic Stroke: A Quantitative Systematic Review.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Edaravone dexborneol in acute ischemic stroke: a systematic review and meta-analysis of randomized trials with clinical and thrombectomy-specific subgroup analyses.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Neutrophil to high-density lipoprotein cholesterol ratio and prognosis in acute ischemic stroke: a systematic review and meta-analysis.BMC neurology · 2026Pooled it
- Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.Neurocritical care · 2026Guideline
- Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Detection of Hemorrhagic Transformation of Cerebral Infarcts with Ultra-low Field MRI.Clinical neuroradiology · 2026Article
- Hemorrhagic transformation following a malignant middle cerebral artery infarction.Journal of cerebrovascular and endovascular neurosurgery · 2026Article
- Prognostic Value of the Cholesterol, High-Density Lipoprotein, and Glucose Index and Remnant Cholesterol Inflammatory Index in Young Patients with Acute Ischemic Stroke.Journal of clinical medicine · 2026Article
- The Brain-Atrial Fibrillation-Recent Rehabilitation Axis: A Modern Approach.Healthcare (Basel, Switzerland) · 2026Review
- Volumetric Infarct Size Predicts Secondary Haemorrhagic Transformation of Ischaemic Stroke.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- CT perfusion ischemic core predicts PH-2 hemorrhagic transformation following intravenous alteplase bridging treatment prior to endovascular thrombectomy.Therapeutic advances in neurological disorders · 2026Article
- Zero anticoagulation, zero thrombolysis: successful management of massive pulmonary embolism following hemorrhagic transformation of acute ischemic stroke: a case report.Frontiers in cardiovascular medicine · 2026Article
- Distinct spatiotemporal patterns of white matter hyperintensity progression.Nature communications · 2025Article
- Cardiovascular Risk Factors Involved in Hemorrhagic Transformation After Intravenous Thrombolytic Therapy in Patients with Acute Ischemic Stroke.International journal of molecular sciences · 2025Review
- Optimal Timing of Post-Alteplase Brain Computed Tomography: Routine Twenty-Four-Hour Versus Extended Forty-Eight-Hour for Detecting Asymptomatic Intracranial Hemorrhage.Journal of clinical medicine research · 2025Article
- Deep learning of noncontrast CT for fast prediction of hemorrhagic transformation of acute ischemic stroke: a multicenter study.European radiology experimental · 2025Article
- The role of ASPECTS score, atrial fibrillation, and revascularization therapy in predicting hemorrhagic transformation of ischemic stroke: results from a prospective cohort study.Frontiers in neurology · 2025Article
- A Case of Development and Rapid Increase in the Microbleeds after Pipeline Placement for an Intracranial Unruptured Aneurysm.NMC case report journal · 2025Article
- Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes.Annals of clinical and translational neurology · 2025Article
- Intravenous thrombolysis prevents neurological deterioration in patients with acute pontine infarction.Frontiers in neurology · 2025Article
- Prediction of hemorrhagic transformation after thrombolysis based on machine learning models combined with platelet distribution width-to-count ratio.Frontiers in neurology · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence and risk factors of hemorrhagic transformation (HT) after acute ischemic stroke HT have not been adequately delineated. We performed a systematic review and meta-analysis to identify English-language prospective observational MEDLINE and EMBASE-listed reports of acute ischemic stroke with HT published from 1985-2017. Studies that used the ECASS-2 definitions of hemorrhagic transformation subtypes, hemorrhagic infarction (HI), and parenchymal hematoma (PH) were included. Patients treated with intravenous thrombolysis with tissue plasminogen activator (IV-tPA) were compared with those who did not receive thrombolysis. A total of 65 studies with 17,259 patients met inclusion criteria. Overall, HT prevalence was 27%; 32% in patients receiving IV-tPA vs. 20% in those without. Overall PH prevalence was 9%; 12% in IV-tPA treated patients vs. 5% in those without. HT was associated with a history of atrial fibrillation (OR 2.94) and use of anticoagulants (OR 2.47). HT patients had higher NIHSS (Hedge's-G 0.96) and larger infarct volume (diffusion-weighted MRI, Hedge's-G 0.8). In IV-tPA treated patients, PH correlated with antiplatelet (OR 3) and statin treatment (OR 4). HT (OR 3) and PH (OR 8) were associated with a poor outcome at 90-day (mRS 5-6). Hemorrhagic transformation is a frequent complication of acute ischemic stroke and is associated with poor outcome. Recognition of risk factors for HT and PH may reduce their incidence and severity.
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