ArticleAnimals : an open access journal from MDPI2022
The Candidate Chromosomal Regions Responsible for Milk Yield of Cow: A GWAS Meta-Analysis.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- A meta-analysis of genome-wide association studies to identify candidate genes associated with feed efficiency traits in pigs.Journal of animal science · 2025Pooled it
- Estimation of Genetic Parameters and Stability for Milk Production Traits in Huaxi Cattle from the Xinjiang Region.Animals : an open access journal from MDPI · 2025Article
- Genomic characterization of normal and aberrant human milk production.Science advances · 2025Article
- Genome-wide association studies for milk production traits and persistency of first calving Holstein cattle in Türkiye.Frontiers in veterinary science · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Milk yield (MY) is highly heritable and an economically important trait in dairy livestock species. To increase power to detect candidate genomic regions for this trait, we carried out a meta-analysis of genome-wide association studies (GWAS). In the present study, we identified 19 studies in PubMed for the meta-analysis. After review of the studies, 16 studies passed the filters for meta-analysis, and the number of chromosomes, detected markers and their positions, number of animals, and p-values were extracted from these studies and recorded. The final data set based on 16 GWAS studies had 353,698 cows and 3950 markers and was analyzed using METAL software. Our findings revealed 1712 significant (p-value < 2.5 × 10−6) genomic loci related to MY, with markers associated with MY found on all autosomes and sex chromosomes and the majority of them found on chromosome 14. Furthermore, gene ontology (GO) annotation was used to explore biological functions of the genes associated with MY; therefore, different regions of this chromosome may be suitable as genomic regions for further research into gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.