SynthesisNutrients2022
Vitamin D Levels in Early and Middle Pregnancy and Preeclampsia, a Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Comparative effectiveness of statins, metformin, and vitamin D, for prevention of preeclampsia: a systematic review and network meta-analysis of randomized trials.BMC pregnancy and childbirth · 2026Pooled it
- Vitamin D levels in early and middle pregnancy and preeclampsia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Efficacy of vitamin D supplementation on the incidence of preeclampsia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis.Clinical nutrition ESPEN · 2022Pooled it
- The impact of folic acid supplementation in early to mid-pregnancy on the risk of hypertensive disorders of pregnancy: the Japan environment and children's study.BMC pregnancy and childbirth · 2026Article
- Maternal Vitamin D Status, Gestational Hypertension, and Preeclampsia: A Cross-Sectional Study in Urban Greece.Biomedicines · 2025Article
- Correlation between anthropometric and biological parameters of the offspring and parental plasma 25-hydroxyvitamin D levels: a cross-sectional study conducted at Oran, Algeria.BMC pregnancy and childbirth · 2025Article
- Evaluation of placental growth factor, Vitamin D, and systemic inflammatory index as predictive biomarkers for preeclampsia severity: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Unraveling the gut microbiota-SCFAs-cathepsin C pathway in preeclampsia: a novel therapeutic target.Frontiers in immunology · 2025Article
- Impacts of Maternal Preeclampsia Exposure on Offspring Neuronal Development: Recent Insights and Interventional Approaches.International journal of molecular sciences · 2024Review
- Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study.Frontiers in cellular and infection microbiology · 2024Article
- Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand.Frontiers in nutrition · 2024Article
- Association of Reduced Maternal Plasma Cholinesterase Activity With Preeclampsia: A Meta-Analysis.Cureus · 2023Review
- Micronutrients in Pregnancy after Bariatric Surgery: A Narrative Review.Journal of clinical medicine · 2023Review
- The Effects of Vitamin D Supplementation before 20 Weeks of Gestation on Preeclampsia: A Systematic Review.Journal of personalized medicine · 2023Review
- Article
- A systematic review and meta-analysis of prevalence of vitamin D deficiency among Indonesian pregnant women: a public health emergency.AJOG global reports · 2023Review
- Systematic evaluation of the pre-eclampsia drugs, dietary supplements and biologicals pipeline using target product profiles.BMC medicine · 2022Article
- Effects of Vitamin D on Fertility, Pregnancy and Polycystic Ovary Syndrome-A Review.Nutrients · 2022Review
- Modulatory Effects of Vitamin D: A Possible Approach to Mitigate Air Pollution Related Pregnancy Complications.Journal of reproduction & infertilityReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D (VitD) shows a beneficial role in placentation, the immune system, and angiogenesis, and thus, VitD status may link to the risk of preeclampsia. A meta-analysis was conducted to investigate the association between VitD status in early and middle pregnancy and the risk of preeclampsia. A total of 22 studies with 25,530 participants were included for analysis. Women with VitD insufficiency or deficiency had a higher preeclampsia rate compared to women with replete VitD levels (OR 1.58, 95% CI 1.39-1.79). Women with VitD deficiency had a higher preeclampsia rate compared to women with replete or insufficient VitD levels (OR 1.35, 95% CI 1.10-1.66). Women with insufficient VitD levels had a higher preeclampsia rate compared to women with replete VitD levels (OR 1.44, 95% CI 1.24-1.66). Women with deficient VitD levels had a higher preeclampsia rate compared to women with replete VitD levels (OR 1.50, 95% CI 1.05-2.14). Sensitivity analysis showed the results were stable after excluding any one of the included studies. In conclusion, our systematic review suggested that VitD insufficiency or deficiency was associated with an increased risk of preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.