Evidence map›Paper›PMID 35267907›Full record

ReviewNutrients2022

Effects of Creatine Supplementation on Brain Function and Health.

Scott C Forbes, Dean M Cordingley, Stephen M Cornish, Bruno Gualano, Hamilton Roschel, Sergej M Ostojic, Eric S Rawson, Brian D Roy, Konstantinos Prokopidis, Panagiotis Giannos and 1 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06576466 (Effect of Supplementation With Creatine on the Early Recovery of Ischemic Stroke), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06576466 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Supplementation With Creatine on the Early Recovery of Ischemic Stroke: A Randomized Clinical Trial

TypeinterventionalSponsorFundació d'investigació Sanitària de les Illes BalearsRan2024 to 2027Enrolled92ConditionsStroke, IschemicArmsCreatine monohydrate, Placebo
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Systematic review ofFrontiers in aging neuroscience · 2023
    Pooled it
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  12. Review
  13. Article
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  18. Creatine monohydrate supplementation for older adults and clinical populations.Journal of the International Society of Sports Nutrition · 2025
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 6 countries.

Scott C ForbesDepartment of Physical Education Studies, Faculty of Education, Brandon University, Brandon, MB R7A 6A9, Canada.ORCID 0000-0001-6896-5552
Dean M CordingleyApplied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Stephen M CornishCentre for Aging, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0002-0801-6707
Bruno GualanoApplied Physiology & Nutrition Research Group, Rheumatology Division, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil.
Hamilton RoschelApplied Physiology & Nutrition Research Group, Rheumatology Division, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil.ORCID 0000-0002-9513-6132
Sergej M OstojicDepartment of Nutrition and Public Health, University of Agder, 4604 Kristiansand, Norway.ORCID 0000-0002-7270-2541
Eric S RawsonDepartment of Health, Nutrition, and Exercise Science, Messiah University, Mechanicsburg, PA 17055, USA.
Brian D RoyDepartment of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.ORCID 0000-0003-4638-5586
Konstantinos ProkopidisDepartment of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L73 FAK, UK.
Panagiotis GiannosDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-1037-1983
Darren G CandowFaculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, Canada.
Universidade de São Paulo · BRUniversity of Manitoba · CABrock University · CAImperial College London · GBMessiah University · USPan Am Clinic · CAUniversity of Liverpool · GBUniversity of Novi Sad · RSUniversity of Regina · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. The purpose of this narrative review is to summarize the current body of research pertaining to creatine supplementation on total creatine and phophorylcreatine (PCr) content, explore GAA as an alternative or adjunct to creatine supplementation on brain creatine uptake, assess the impact of creatine on cognition with a focus on sleep deprivation, discuss the effects of creatine supplementation on a variety of neurological and mental health conditions, and outline recent advances on creatine supplementation as a neuroprotective supplement following traumatic brain injury or concussion.

Indexed as

CreatineNervous System Physiological PhenomenaBrainDietary SupplementsHumansMuscle, SkeletalCreatineamino acidsdepressionmental healthsupplementation

Identifiers

PMID35267907
PMCPMC8912287
OpenAlexW4214522814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.