ReviewPolymers2022
Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review.
Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Interface Control of Poly(L-lactic Acid)/Hydroxyapatite Composites by Using Bisphosphonate.ACS omega · 2026Article
- Silver-Doped Mesoporous Calcium Phosphate for Controlled Amoxicillin Delivery and Modulation of Osteoblast-like Cell Response.Pharmaceutics · 2026Article
- Strategies to Enhance Yield of Wet-Synthesized Hydroxyapatite Nanocrystals and Consequences for Drug-Release Kinetics.Materials (Basel, Switzerland) · 2025Article
- Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications.International dental journal · 2025Review
- Therapeutic applications of red marine seaweeds in dental care: innovations in oral health and treatment.Biomaterial investigations in dentistry · 2025Article
- Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair.Regenerative biomaterials · 2024Article
- Insight into the integration effect of chitosan and β-cyclodextrin on the properties of zinc-phosphate/hydroxyapatite hybrid as delivery structures for 5-fluorouracil: loading and release profiles.Frontiers in chemistry · 2024Article
- Photothermal Conversion Efficiency of Silver and Gold Incorporated Nanosized Apatites for Biomedical Applications.ACS omega · 2023Article
- Gallium-Doped Hydroxyapatite: Shape Transformation and Osteogenesis Activity.Molecules (Basel, Switzerland) · 2023Article
- Synthesis and characterization of Mg-hydroxyapatite and its cellulose hybridized structure as enhanced bio-carrier of oxaliplatin drug; equilibrium and release kinetics.RSC advances · 2023Article
- Article
- In vitro and in vivo Evaluation of Folic Acid Modified DOX-LoadedInternational journal of nanomedicine · 2023Article
- Article
- Modulated Laser Cladding of Implant-Type Coatings by Bovine-Bone-Derived Hydroxyapatite Powder Injection on Ti6Al4V Substrates-Part I: Fabrication and Physico-Chemical Characterization.Materials (Basel, Switzerland) · 2022Article
- Low Concentrations of Silver Nanoparticles Inhibit Spore Germination and Disturb Gender Differentiation ofNanomaterials (Basel, Switzerland) · 2022Article
- Enhancement of Anticorrosive Performance of Cardanol Based Polyurethane Coatings by Incorporating Magnetic Hydroxyapatite Nanoparticles.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.