Evidence map›Paper›PMID 35267754›Full record

ReviewPolymers2022

Recent Progress on Heparin-Protamine Particles for Biomedical Application.

Yuuki Hata, Hiromi Miyazaki, Masayuki Ishihara, Shingo Nakamura

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yuuki HataDivision of Biomedical Engineering, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa-shi 359-8513, Saitama, Japan.ORCID 0000-0003-1493-1896
Hiromi MiyazakiDivision of Biomedical Engineering, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa-shi 359-8513, Saitama, Japan.ORCID 0000-0001-7719-4913
Masayuki IshiharaDivision of Biomedical Engineering, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa-shi 359-8513, Saitama, Japan.
Shingo NakamuraDivision of Biomedical Engineering, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa-shi 359-8513, Saitama, Japan.ORCID 0000-0001-6084-0958
National Defense Medical College · JP

Funding

Japan Society for the Promotion of Science JP20K21912Japan Society for the Promotion of Science JP21K14688
6 · The paper itself

Abstract

Biomolecules are attractive building blocks with self-assembly ability, structural diversity, and excellent functionality for creating artificial materials. Heparin and protamine, a clinically relevant pair of biomolecules used in cardiac and vascular surgery, have been shown to coassemble into particulate polyelectrolyte complexes in vitro. The resulting heparin-protamine particles exhibit adhesive properties that enable advantageous interactions with proteins, cells, and various other substances and have been employed as functional materials for biomedical applications. In this review article, we summarize recent progress in research on the use of heparin-protamine particles as drug carriers, cell adhesives, and cell labels. Studies have demonstrated that heparin-protamine particles are potentially versatile in biomedical fields from drug delivery and regenerative medicine to plastic surgery.

Indexed as

biomedical applicationheparinmicroparticlemolecular self-assemblynanoparticlepolyelectrolyte complexprotamine

Identifiers

PMID35267754
PMCPMC8912589
OpenAlexW4214675403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.