Evidence map›Paper›PMID 35267750›Full record

ArticlePolymers2022

Construction of Konjac Glucomannan/Oxidized Hyaluronic Acid Hydrogels for Controlled Drug Release.

Hongyi Wu, Nitong Bu, Jie Chen, Yuanyuan Chen, Runzhi Sun, Chunhua Wu, Jie Pang

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hongyi WuCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Nitong BuCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Jie ChenCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Yuanyuan ChenCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Runzhi SunCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Chunhua WuCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Jie PangCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Fujian Agriculture and Forestry University · CN

Funding

Fujian Science and Technology Planning Project 2018N2002Fuzhou Science and Technology Bureau 2019-G-50National Natural Science Foundation of China 31772045
6 · The paper itself

Abstract

Konjac glucomannan (KGM) hydrogel has favorable gel-forming abilities, but its insufficient swelling capacity and poor control release characteristics limit its application. Therefore, in this study, oxidized hyaluronic acid (OHA) was used to improve the properties of KGM hydrogel. The influence of OHA on the structure and properties of KGM hydrogels was evaluated. The results show that the swelling capacity and rheological properties of the composite hydrogels increased with OHA concentration, which might be attributed to the hydrogen bond between the KGM and OHA, resulting in a compact three-dimensional gel network structure. Furthermore, epigallocatechin gallate (EGCG) was efficiently loaded into the KGM/OHA composite hydrogels and liberated in a sustained pattern. The cumulative EGCG release rate of the KGM/OHA hydrogels was enhanced by the increasing addition of OHA. The results show that the release rate of composite hydrogel can be controlled by the content of OHA. These results suggest that OHA has the potential to improve the properties and control release characteristics of KGM hydrogels.

Indexed as

hydrogelskonjac glucomannanoxidized hyaluronic acid

Identifiers

PMID35267750
PMCPMC8912606
OpenAlexW4214614032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.