Evidence map›Paper›PMID 35267619›Full record

ArticleCancers2022

Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways.

Khoa Pham, Allison R Hanaford, Brad A Poore, Micah J Maxwell, Heather Sweeney, Akhila Parthasarathy, Jesse Alt, Rana Rais, Barbara S Slusher, Charles G Eberhart and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Khoa PhamDivision of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Allison R HanafordDivision of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Brad A PooreDivision of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Micah J MaxwellDivision of Pediatric Oncology, Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Heather SweeneyDivision of Pediatric Oncology, Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Akhila ParthasarathyDivision of Pediatric Oncology, Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Jesse AltJohns Hopkins Drug Discovery, Baltimore, MD 21205, USA.
Rana RaisJohns Hopkins Drug Discovery, Baltimore, MD 21205, USA.ORCID 0000-0003-4059-2453
Barbara S SlusherJohns Hopkins Drug Discovery, Baltimore, MD 21205, USA.
Charles G EberhartDivision of Neuropathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Eric H RaabeDivision of Pediatric Oncology, Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-9368-7037
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Opportunities for Pathology Trainees in Cancer ResearchT32CA193145 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANDERS, ROBERT A., EBERHART, CHARLES G · 2015 to 2025
$2.6M
Novel brain penetrant metabolic inhibitors to treat MYC-driven medulloblastomaR01NS103927 · NINDS · JOHNS HOPKINS UNIVERSITY · PI RAABE, ERIC HUTTON, SLUSHER, BARBARA STAUCH · 2018 to 2021
$1.6M
NCI NIH HHS P30CA006973NCI NIH HHS T32 CA193145NINDS NIH HHS 1R01NS103927NINDS NIH HHS R01 NS103927
6 · The paper itself

Abstract

Reprograming of cellular metabolism is a hallmark of cancer. Altering metabolism allows cancer cells to overcome unfavorable microenvironment conditions and to proliferate and invade. Medulloblastoma is the most common malignant brain tumor of children. Genomic amplification of

Indexed as

cancer metabolismisotope labelingmass spectrometrypediatric brain tumorWarburg effect

Identifiers

PMID35267619
PMCPMC8909278
OpenAlexW4214914185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.