Evidence map›Paper›PMID 35267608›Full record

ArticleCancers2022

Comparison of Active Surveillance to Stereotactic Radiosurgery for the Management of Patients with an Incidental Frontobasal Meningioma-A Sub-Analysis of the IMPASSE Study.

Abdurrahman I Islim, Georgios Mantziaris, Stylianos Pikis, Ching-Jen Chen, Adomas Bunevicius, Selçuk Peker, Yavuz Samanci, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros and 20 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 16 institutions in 10 countries.

Abdurrahman I IslimDepartment of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK.ORCID 0000-0001-9621-043X
Georgios MantziarisDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-3389-8836
Stylianos PikisDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Ching-Jen ChenDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Adomas BuneviciusDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Selçuk PekerDepartment of Neurosurgery, Koc University School of Medicine, Istanbul 34010, Turkey.ORCID 0000-0003-3057-3355
Yavuz SamanciDepartment of Neurosurgery, Koc University School of Medicine, Istanbul 34010, Turkey.ORCID 0000-0001-8952-6866
Ahmed M NabeelGamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt.
Wael A RedaGamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt.
Sameh R TawadrosGamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt.
Amr M N El-ShehabyGamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt.
Khaled AbdelkarimGamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt.
Reem M EmadGamma Knife Center Cairo, Nasser Institute, Cairo 11796, Egypt.
Violaine DelabarCentre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
David MathieuCentre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID 0000-0003-2029-6315
Cheng-Chia LeeDepartment of Neurosurgery, School of Medicine, Neurological Institute, Taipei Veteran General Hospital, Taipei City 11217, Taiwan.
Huai-Che YangDepartment of Neurosurgery, School of Medicine, Neurological Institute, Taipei Veteran General Hospital, Taipei City 11217, Taiwan.
Roman LiscakDepartment of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, 150 00 Prague, Czech Republic.
Jaromir MayDepartment of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, 150 00 Prague, Czech Republic.
Roberto Martinez AlvarezDepartment of Radiosurgery, Rúber International Hospital, 28034 Madrid, Spain.
Nuria Martinez MorenoDepartment of Radiosurgery, Rúber International Hospital, 28034 Madrid, Spain.
Manjul TripathiDepartment of Neurosurgery and Radiotherapy, Nehru Hospital Sector 12, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Punjab, India.ORCID 0000-0002-5679-3439
Douglas KondziolkaDepartment of Neurosurgery, New York University, New York, NY 10016, USA.
Herwin SpeckterDepartment of Radiology, Dominican Gamma Knife Center and CEDIMAT, Santo Domingo 10514, Dominican Republic.ORCID 0000-0002-9904-2395
Camilo AlbertDepartment of Radiology, Dominican Gamma Knife Center and CEDIMAT, Santo Domingo 10514, Dominican Republic.
Greg N BowdenDepartment of Neurosurgery, 2D1.02 Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Ronald J BenvenisteDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lawrence Dade LunsfordDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Jason P SheehanDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Michael D JenkinsonDepartment of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK.ORCID 0000-0003-4587-2139
Neurological Surgery · USAin Shams University · EGHospital Ruber Internacional · ESInstituto Tecnológico de Santo Domingo · DOKoç University · TRNa Homolce Hospital · CZNational Yang Ming Chiao Tung University · TWUniversité de Sherbrooke · CAUniversity of Liverpool · GBBenha University · EGCairo University · EGNew York University · USPost Graduate Institute of Medical Education and Research · INUniversity of Alberta · CAUniversity of Miami · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningioma is a common incidental finding, and clinical course varies based on anatomical location. The aim of this sub-analysis of the IMPASSE study was to compare the outcomes of patients with an incidental frontobasal meningioma who underwent active surveillance to those who underwent upfront stereotactic radiosurgery (SRS). Data were retrospectively collected from 14 centres. The active surveillance (n = 28) and SRS (n = 84) cohorts were compared unmatched and matched for age, sex, and duration of follow-up (n = 25 each). The study endpoints included tumor progression, new symptom development, and need for further intervention. Tumor progression occurred in 52.0% and 0% of the matched active surveillance and SRS cohorts, respectively (p < 0.001). Five patients (6.0%) treated with SRS developed treatment related symptoms compared to none in the active monitoring cohort (p = 0.329). No patients in the matched cohorts developed symptoms attributable to treatment. Three patients managed with active surveillance (10.7%, unmatched; 12.0%, matched) underwent an intervention for tumor growth with no persistent side effects after treatment. No patients subject to SRS underwent further treatment. Active monitoring and SRS confer a similarly low risk of symptom development. Upfront treatment with SRS improves imaging-defined tumor control. Active surveillance and SRS are acceptable treatment options for incidental frontobasal meningioma.

Indexed as

asymptomaticincidentalmeningiomaradiosurgerysurveillance

Identifiers

PMID35267608
PMCPMC8909178
OpenAlexW4214877973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.