Evidence map›Paper›PMID 35267591›Full record

ArticleCancers2022

Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma.

Morgane Le Bras, Noah Gorelick, Sylvain Pautet, Betty Tyler, Stéphane Manenti, Nicolas Skuli, Stefania Millevoi, Anne Cammas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. The HNRNPF/H RNA binding proteins and disease.Wiley interdisciplinary reviews. RNA
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Morgane Le BrasCancer Research Centre of Toulouse, INSERM UMR 1037, 31037 Toulouse, France.
Noah GorelickHunterian Neurosurgical Research Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1313-1061
Sylvain PautetUniversité Toulouse III Paul Sabatier, 31330 Toulouse, France.
Betty TylerHunterian Neurosurgical Research Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9800-6969
Stéphane ManentiCancer Research Centre of Toulouse, INSERM UMR 1037, 31037 Toulouse, France.
Nicolas SkuliHunterian Neurosurgical Research Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Stefania MillevoiCancer Research Centre of Toulouse, INSERM UMR 1037, 31037 Toulouse, France.
Anne CammasCancer Research Centre of Toulouse, INSERM UMR 1037, 31037 Toulouse, France.
Université Toulouse III - Paul Sabatier · FRJohns Hopkins University · US

Funding

Agence Nationale de la Recherche ANR-17-CE12-0017-01Association pour la Recherche sur le Cancer PJA 20151203413Emergence Cancéropole GSO 2015-E02Institut National de la Santé et de la Recherche Médicale Institutional grantLaboratoire d'excellence TOUCAN ANR11-LABXMidi-Pyrénées Region/INSERM PhD fellowshipNIH HHS Institutional grant
6 · The paper itself

Abstract

Deregulation of mRNA translation is a widespread characteristic of glioblastoma (GBM), aggressive malignant brain tumors that are resistant to conventional therapies. RNA-binding proteins (RBPs) play a critical role in translational regulation, yet the mechanisms and impact of these regulations on cancer development, progression and response to therapy remain to be fully understood. Here, we showed that hnRNP H/F RBPs are potent regulators of translation through several mechanisms that converge to modulate the expression and/or the activity of translation initiation factors. Among these, hnRNP H/F regulate the phosphorylation of eIF4E and its translational targets by controlling RNA splicing of the

Indexed as

glioblastomahnRNP H/FRNA-binding proteinRNA G-quadruplextranslation

Identifiers

PMID35267591
PMCPMC8909726
OpenAlexW4214807123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.