ArticleCancers2022
Factors Associated with Nodal Upstaging in Clinical T1a-bN0M0 Non-Small Cell Lung Cancers.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Nodal upstaging and neoadjuvant therapy in lung adenocarcinoma: Evidence of a missed opportunity?JTCVS open · 2026Article
- Outcome of segmentectomy vs. lobectomy in patients with cT1a-b N0 lung cancer and postoperative N1 upstaging.Langenbeck's archives of surgery · 2026Article
- Survival of patients with node-negative lung cancer and chest wall invasion.Journal of thoracic disease · 2025Article
- Absent preoperative non-small cell lung cancer confirmation and relevant stage migration in the era before neoadjuvant chemoimmunotherapy: implications for treatment decisions in resectable non-small cell lung cancer.Translational lung cancer research · 2025Article
- Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience.Current oncology (Toronto, Ont.) · 2025Article
- Case report: Occult lymph nodal metastasis in sub-centimeter lung cancer: a report of seven cases and review of literature.Frontiers in oncology · 2025Article
- The prognostic significance of right paratracheal lymph node dissection numbers in right upper lobe non-small cell lung cancer.Updates in surgery · 2024Article
- Imaging diagnostics of pulmonary ground-glass nodules: a narrative review with current status and future directions.Quantitative imaging in medicine and surgery · 2024Review
- Distinct impacts of radiological appearance on lymph node metastasis and prognosis based on solid size in clinical T1 non-small cell lung cancer.Respiratory research · 2024Article
- Article
- Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer.Precision clinical medicine · 2023Article
- Nomograms for intraoperative prediction of lymph node metastasis in clinical stage IA lung adenocarcinoma.Cancer medicine · 2023Article
- Programmed death ligand-1 expression and occult lymph node metastasis in non-small cell lung cancer.Thoracic cancer · 2023Article
- [Research Progress in the Effect of Consolidation Tumor Ratio on the Diagnosis and Treatment of Early-stage Peripheral Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Nodal upstaging of lung adenocarcinoma occurs when unexpected pathological lymph node metastasis is found after surgical intervention, and may be associated with a worse prognosis. In this study, we aimed to determine the predictive factors of nodal upstaging in cT1a-bN0M0 primary lung adenocarcinoma. We retrospectively reviewed a prospective database (January 2011 to May 2017) at National Taiwan University Hospital and identified patients with cT1a-bN0M0 (solid part tumor diameter ≤ 2 cm) lung adenocarcinoma who underwent video-assisted thoracoscopic lobectomy. Logistic regression models and survival analysis were used to examine and compare the predictive factors of nodal upstaging. A total of 352 patients were included. Among them, 28 (7.8%) patients had nodal upstaging. Abnormal preoperative serum carcinoembryonic antigen (CEA) levels, solid part tumor diameter ≥ 1.3 cm, and consolidation-tumor (C/T) ratio ≥ 0.50 on chest computed tomography (CT) were significant predictive factors associated with nodal upstaging, and patients with nodal upstaging tended to have worse survival. Standard lobectomy is recommended for patients with these predictive factors. If neither of the predictive factors are positive, a less invasive procedure may be a reasonable alternative. Further studies are needed to verify these data.
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