Evidence map›Paper›PMID 35267477›Full record

ArticleCancers2022

Evaluating Alternative Ramucirumab Doses as a Single Agent or with Paclitaxel in Second-Line Treatment of Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma: Results from Two Randomized, Open-Label, Phase II Studies.

Manish A Shah, Anghel Adrian Udrea, Igor Bondarenko, Was Mansoor, Raquel Guardeño Sánchez, Tomasz Sarosiek, Silvia Bozzarelli, Michael Schenker, Carlos Gomez-Martin, Carys Morgan and 20 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 13 countries.

Manish A ShahDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY 10021, USA.ORCID 0000-0002-6913-9655
Anghel Adrian UdreaCancer Center, Medisprof SRL, 400641 Cluj-Napoca, Romania.
Igor BondarenkoDepartment of Oncology, Dnipropetrovsk Medical Academy, 49044 Dnipropetrovsk, Ukraine.
Was MansoorDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK.
Raquel Guardeño SánchezDepartment of Medical Oncology, Catalan Institute of Oncology (ICO) Girona Hospital Dr Josep Trueta, 17007 Girona, Spain.ORCID 0000-0002-6462-132X
Tomasz SarosiekDepartment of Clinical Oncology and Oncological Surgery, LUXMED Onkologia, 04125 Warszawa, Poland.
Silvia BozzarelliMedical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, 20089 Milan, Italy.ORCID 0000-0002-8118-7342
Michael SchenkerCentrul de Oncologie Sf. Nectarie SRL, 200542 Craiova, Romania.
Carlos Gomez-MartinMedical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Carys MorganDepartment of Clinical Oncology, Velindre Cancer Centre, Cardiff CF14 2TL, UK.
Mustafa ÖzgüroğluMedical Oncology, Istanbul University, Cerrahpaşa, Fatih, Istanbul 34098, Turkey.ORCID 0000-0002-8417-8628
Joanna PikielDepartment of Oncology, Copernicus Podmiot Leczniczy, 80-803 Gdańsk, Poland.
Haralabos P KalofonosDepartment of Oncology, University General Hospital of Patras Rion, 26504 Patras, Greece.
Elzbieta WojcikNZOZ Centrum Medyczne HCP, 62-030 Luboń, Poland.
Tomas BuchlerDepartment of Oncology, First Faculty of Medicine, Charles University and Thomayer University Hospital, 14059 Prague, Czech Republic.ORCID 0000-0001-6667-994X
Daniel SwinsonInstitute of Oncology, St James's University Hospital, Leeds LS9 7TF, UK.
Irfan CicinMedical Oncology, Trakya University, Edirne 22030, Turkey.ORCID 0000-0002-7584-3868
Mano JosephDeanesly Centre, New Cross Hospital, Wolverhamptom WV10 0QP, UK.
Ihor VynnychenkoSumy Regional Oncology Center, Sumy State University, 40000 Sumy, Ukraine.
Alexander Valerievich LuftDepartment of Oncology No 1 (Thoracic Surgery), Leningrad Regional Clinical Hospital, 194291 St. Petersburg, Russia.
Peter C EnzingerMedical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Tomas SalekDepartment of Clinical Oncology, Narodny Onkologicky Ustav, 83310 Bratislava, Slovakia.
Christos PapandreouDepartment of Medical Oncology, Faculty of Medicine, University of Thessaly, Biopolis, 41223 Larissa, Greece.
Christophe TournigandDepartment of Medical Oncology, Henri Mondor et Albert Chenevier Teaching Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris-Est Creteil, 94000 Créteil, France.
Evaristo MaielloOncology Unit, Foundation Casa Sollievo della Sofferenza IRCCS, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0003-3890-3435
Ran WeiEli Lilly and Company, Indianapolis, IN 46225, USA.
David FerryEli Lilly and Company, New York, NY 10016, USA.
Ling GaoEli Lilly and Company, New York, NY 10016, USA.
Joana M OliveiraEli Lilly and Company, New York, NY 10016, USA.
Jaffer A AjaniDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Eli Lilly (United States) · USCasa Sollievo della Sofferenza · ITCatalan Institute for Water Research · ESCharles University · CZCornell University · USDana-Farber Cancer Institute · USDnipro State Medical University · UAGeneral University Hospital of Patras · GRHospital Universitario 12 De Octubre · ESIRCCS Humanitas Research Hospital · ITIstanbul University-Cerrahpaşa · TRLeningrad Regional Cancer Center · RUNárodný Onkologický Ústav · SKNew Cross Hospital · GBNZOZ Centrum Alergologii · PLSt James's University Hospital · GBSumy State University · UAThe Christie NHS Foundation Trust · GBThe University of Texas MD Anderson Cancer Center · USTrakya University · TR

Funding

Eli Lilly and Company, USA N/A
6 · The paper itself

Abstract

Studies JVDB and JVCZ examined alternative ramucirumab dosing regimens as monotherapy or combined with paclitaxel, respectively, in patients with advanced/metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. For JVDB, randomized patients (

Indexed as

angiogenesisgastric adenocarcinomaramucirumabvascular endothelial growth factor receptor

Identifiers

PMID35267477
PMCPMC8909008
OpenAlexW4213428290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.