Evidence map›Paper›PMID 35267456›Full record

ArticleCancers2022

Human Cytomegalovirus Seropositivity and Viral DNA in Breast Tumors Are Associated with Poor Patient Prognosis.

Zelei Yang, Xiaoyun Tang, Maria Eloisa Hasing, Xiaoli Pang, Sunita Ghosh, Todd P W McMullen, David N Brindley, Denise G Hemmings

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Does human cytomegalovirus provide a novel therapeutic target for patients with glioblastoma?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  5. Article
  6. Observational
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zelei YangDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.
Xiaoyun TangDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.
Maria Eloisa HasingDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2B7, Canada.ORCID 0000-0002-4047-4476
Xiaoli PangDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Sunita GhoshMedical Oncology, Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB T6G 1Z2, Canada.
Todd P W McMullenCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2S2, Canada.
David N BrindleyDepartment of Biochemistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.ORCID 0000-0003-2227-0020
Denise G HemmingsCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2S2, Canada.
University of Alberta · CA

Funding

Canadian Breast Cancer Foundation 300034Canadian Cancer Society Research Institute 300034CIHR MOP123488CIHR PJT-169140Li Ka Shing Institute of Virology NoneWomen and Children's Health Research Institute None
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) infects 40-70% of adults in developed countries. Detection of HCMV DNA and/or proteins in breast tumors varies considerably, ranging from 0-100%. In this study, nested PCR to detect HCMV glycoprotein B (gB) DNA in breast tumors was shown to be sensitive and specific in contrast to the detection of DNA for immediate early genes. HCMV gB DNA was detected in 18.4% of 136 breast tumors while 62.8% of 94 breast cancer patients were seropositive for HCMV. mRNA for the HCMV immediate early gene was not detected in any sample, suggesting viral latency in breast tumors. HCMV seropositivity was positively correlated with age, body mass index and menopause. Patients who were HCMV seropositive or had HCMV DNA in their tumors were 5.61 (CI 1.77-15.67,

Indexed as

glycoprotein BlatencymetastasisoncomodulatoryPCR methodsrelapse-free survivaltumor recurrence

Identifiers

PMID35267456
PMCPMC8909033
OpenAlexW4213450087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.