Evidence map›Paper›PMID 35267382›Full record

ArticleFoods (Basel, Switzerland)2022

Effects of Selenium Nanoparticles on Preventing Patulin-Induced Liver, Kidney and Gastrointestinal Damage.

Yue Qiu, Xinlu Chen, Zhangxi Chen, Xuejun Zeng, Tianli Yue, Yahong Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yue QiuCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
Xinlu ChenCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
Zhangxi ChenCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.
Xuejun ZengCollege of Food Science and Engineering, Northwest A&F University, Xianyang 712100, China.
Tianli YueCollege of Food Science and Engineering, Northwest A&F University, Xianyang 712100, China.
Yahong YuanCollege of Food Science and Engineering, Northwest A&F University, Xianyang 712100, China.
Northwest A&F University · CNZhejiang University of Technology · CN

Funding

Doctoral Research Foundation of Zhejiang University of Technology 2020133013829
6 · The paper itself

Abstract

Patulin (PAT) is a toxic fungal metabolite, and oxidative damage was proved to be its important toxicity mechanism. Selenium nanoparticles (SeNPs) were prepared by reducing sodium selenite with chitosan as a stabilizer and used for preventing PAT-induced liver, kidney and gastrointestinal damage. SeNPs have good dispersibility, in vitro antioxidant activity, and are much less cytotoxic than sodium selenite. Cell culture studies indicated that SeNPs can effectively alleviate PAT-induced excessive production of intracellular ROS, the decline of glutathione peroxidase activity, and the suppression of cell viability. Evaluation of serum biochemical parameters, histopathology, oxidative stress biomarkers and activities of antioxidant enzymes in a mouse model showed that pre-treatment with SeNPs (2 mg Se/kg body weight) could ameliorate PAT-induced oxidative damage to the liver and kidneys of mice, but PAT-induced gastrointestinal oxidative damage and barrier dysfunction were not recovered by SeNPs, possibly because the toxin doses suffered by the gastrointestinal as the first exposed tissues exceeded the regulatory capacity of SeNPs. These results suggested that a combination of other strategies may be required to completely block PAT toxicity.

Indexed as

antioxidativegastrointestinal damagehepatotoxicitynephrotoxicitypatulinselenium nanoparticles

Identifiers

PMID35267382
PMCPMC8909330
OpenAlexW4220655254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.