Evidence map›Paper›PMID 35267318›Full record

ArticleFoods (Basel, Switzerland)2022

Colostrum-Induced Temporary Changes in the Expression of Proteins Regulating the Epithelial Barrier Function in the Intestine.

Sylwia Rzeszotek, Grzegorz Trybek, Maciej Tarnowski, Karol Serwin, Aleksandra Jaroń, Gabriela Schneider, Agnieszka Kolasa, Barbara Wiszniewska

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sylwia RzeszotekDepartment of Histology and Embryology, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp., 70-111 Szczecin, Poland.ORCID 0000-0002-2157-0315
Grzegorz TrybekDepartment of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp., 70-111 Szczecin, Poland.ORCID 0000-0002-3900-4901
Maciej TarnowskiDepartment of Physiology, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp., 70-111 Szczecin, Poland.ORCID 0000-0002-3869-5077
Karol SerwinDepartment of Infectious Tropical Diseases and Immune Deficiency, Pomeranian Medical University in Szczecin, Arkońska 4, 71-455 Szczecin, Poland.ORCID 0000-0002-1071-8337
Aleksandra JarońDepartment of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp., 70-111 Szczecin, Poland.ORCID 0000-0001-7727-6388
Gabriela SchneiderUofL Health-Brown Cancer Center and Division of Medical Oncology and Hematology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Agnieszka KolasaDepartment of Histology and Embryology, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp., 70-111 Szczecin, Poland.ORCID 0000-0002-6933-7643
Barbara WiszniewskaDepartment of Histology and Embryology, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp., 70-111 Szczecin, Poland.
Pomeranian Medical University · PLUniversity of Louisville · US

Funding

Pomeranian Medical University FSN-167-03/17
6 · The paper itself

Abstract

The intestinal wall and epithelial cells are interconnected by numerous intercellular junctions. Colostrum (Col), in its natural form, is a secretion of the mammary gland of mammals at the end of pregnancy and up to 72 h after birth. Recently, it has been used as a biologically active dietary supplement with a high content of lactoferrin (Lf). Lf, a glycoprotein with a broad spectrum of activity, is becoming more popular in health-promoting supplements. This study aims to investigate whether Col supplementation can affect small and large intestine morphology by modulating the expression of selected proteins involved in tissue integrity. We examined the thickness of the epithelium, and the length of the microvilli, and assessed the expression of

Indexed as

cellular junctionscolostrumintestinelactoferrin

Identifiers

PMID35267318
PMCPMC8909690
OpenAlexW4214530872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.