Evidence map›Paper›PMID 35267087›Full record

ArticleEuropean radiology2022

Quality and safety of coronary computed tomography angiography at academic and non-academic sites: insights from a large European registry (ESCR MR/CT Registry).

Borek Foldyna, Johannes Uhlig, Robin Gohmann, Christian Lücke, Thomas Mayrhofer, Lukas Lehmkuhl, Luigi Natale, Rozemarijn Vliegenthart, Joachim Lotz, Rodrigo Salgado and 9 more

Open access · greenAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Increasing the rate of datasets amenable to CTEuropean journal of radiology open · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 7 countries.

Borek FoldynaCardiovascular Imaging Research Center, Massachusetts General Hospital - Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA, 02114, USA. bfoldyna@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-2466-4827
Johannes UhligDepartment of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Göttingen, Germany.
Robin GohmannDepartment of Diagnostic and Interventional Radiology, Heart Center - University of Leipzig, Leipzig, Germany.
Christian LückeDepartment of Diagnostic and Interventional Radiology, Heart Center - University of Leipzig, Leipzig, Germany.
Thomas MayrhoferCardiovascular Imaging Research Center, Massachusetts General Hospital - Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA, 02114, USA.
Lukas LehmkuhlClinic for Radiology, Rhoen-Klinikum AG, Campus Bad Neustadt, Bad Neustadt an der Saale, Germany.
Luigi NataleCatholic University of the Sacred Heart, Rome, Italy.
Rozemarijn VliegenthartDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Joachim LotzDepartment of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Göttingen, Germany.
Rodrigo SalgadoDepartment of Radiology, Antwerp University Hospital, Antwerp, Belgium.
Marco FranconeDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Christian LoeweDivision of Cardiovascular and Interventional Radiology, Department of Bioimaging, Medical University of Vienna, Vienna, Austria.
Konstantin NikolaouDepartment of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tübingen, Germany.
Fabian BambergDepartment of Diagnostic and Interventional Radiology, Universitäts Klinikum Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
David MaintzDepartment of Diagnostic and Interventional Radiology, University Medical Center Cologne, Cologne, Germany.
Pal Maurovich-HorvatMTA-SE Cardiovascular Imaging Research Group, Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
Holger ThieleDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Udo HoffmannCardiovascular Imaging Research Center, Massachusetts General Hospital - Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA, 02114, USA.
Matthias GutberletDepartment of Diagnostic and Interventional Radiology, Heart Center - University of Leipzig, Leipzig, Germany.
Leipzig Heart Institute · DEHarvard University · USUniversity of Göttingen · DEAntwerp University Hospital · BEHumanitas University · ITMedical University of Vienna · ATRhön-Klinikum · DESemmelweis University · HUUniversità Cattolica del Sacro Cuore · ITUniversity Hospital Cologne · DEUniversity Medical Center Groningen · NLUniversity of Freiburg · DE

Funding

Clinical and Molecular Epidemiology of High Risk Coronary PlaqueR01HL146145 · NHLBI · DUKE UNIVERSITY · PI DOUGLAS, PAMELA SUSAN, FOLDYNA, BOREK · 2019 to 2022
$4.8M
NHLBI NIH HHS R01 HL146145
6 · The paper itself

Abstract

objectivesTo compare the use of coronary computed tomography angiography (CCTA) between academic and non-academic sites across Europe over the last decade.

methodsWe analyzed a large multicenter registry (ESCR MR/CT Registry) of stable symptomatic patients who received CCTA 01/2010-01/2020 at 47 (22%) academic and 165 (78%) non-academic sites across 19 European countries. We compared image quality, radiation dose, contrast-media-related adverse events, patient characteristics, CCTA findings, and downstream testing between academic and non-academic sites.

resultsAmong 64,317 included patients (41% female; 60 ± 13 years), academic sites accounted for most cases in 2010-2014 (52%), while non-academic sites dominated in 2015-2020 (71%). Despite less contemporary technology, non-academic sites maintained low radiation doses (4.76 [2.46-6.85] mSv) with a 30% decline of high-dose scans ( > 7 mSv) over time. Academic and non-academic sites both reported diagnostic image quality in 98% of cases and low rate of scan-related adverse events (0.4%). Academic and non-academic sites examined similar patient populations (41% females both; age: 61 ± 14 vs. 60 ± 12 years; pretest probability for obstructive CAD: low 21% vs. 23%, intermediate 73% vs. 72%, high 6% both, CAD prevalence on CCTA: 40% vs. 41%). Nevertheless, non-academic sites referred more patients to non-invasive ischemia testing (6.5% vs. 4.2%) and invasive coronary angiography/surgery (8.5% vs. 5.6%).

conclusionsNon-academic and academic sites provide safe, high-quality CCTA across Europe, essential to successfully implement the recently updated guidelines for the diagnosis and management of chronic coronary syndromes. However, despite examining similar populations with comparable CAD prevalence, non-academic sites tend to refer more patients to downstream testing. KEY POINTS: • Smaller non-academic providers increasingly use CCTA to rule out obstructive coronary artery disease. • Non-academic and academic sites provide comparably safe, high-quality CCTA across Europe. • Compared to academic sites, non-academic sites tend to refer more patients to downstream testing.

Indexed as

Computed Tomography AngiographyCoronary Artery DiseaseAgedCoronary AngiographyFemaleHumansMaleMiddle AgedRegistriesTomography, X-Ray ComputedChest painChronic stable anginaCoronary artery diseaseMultislice computed tomography

Identifiers

PMID35267087
OpenAlexW4220887581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.