ReviewInternational urogynecology journal2022
International Urogynecological Consultation (IUC): pathophysiology of pelvic organ prolapse (POP).
Review in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The Safety of Robot-Assisted Sacrocolpopexy in Pelvic Organ Prolapse Treatment: Systematic Review and Meta-Analysis.International urogynecology journal · 2025Pooled it
- Transvaginal mesh or grafts or native tissue repair for vaginal prolapse.The Cochrane database of systematic reviews · 2024Pooled it
- PEOPLE: Lifestyle and comorbidities as risk factors for pelvic organ prolapse-a systematic review and meta-analysis PEOPLE: PElvic Organ Prolapse Lifestyle comorbiditiEs.International urogynecology journal · 2023Pooled it
- Long-Term Mesh Exposure 5 Years Following Minimally Invasive Total Hysterectomy and Sacrocolpopexy.International urogynecology journal · 2024Trial
- Tissue Biomarkers Outperform Plasma Signals in Pelvic Organ Prolapse: Evidence of a Dominant Extracellular Matrix Remodelling Phenotype.Current issues in molecular biology · 2026Article
- Pelvic Organ Prolapse with an Emphasis on the Central Compartment: From Genetic Risk Factors and Biomarkers to Contemporary Sacropexy and Emerging Robotic Innovations.Journal of clinical medicine · 2026Review
- The Immediate Impact of Heavy Weightlifting on Pelvic Floor Morphometry in Vaginally Parous Women: A Repeated Measures Study.International urogynecology journal · 2026Article
- Reproductive Complication in Rhesus Macaques (Macaca mulatta): Prevalence, Risk Factors, and Successful Surgical Resolution of Vaginal Prolapse Postpartum.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Chronic Maternal Pelvic Morbidity: A Neglected Tragedy: Where is Pelvic Maternal Morbidity in Maternal and Child Health? : Advocating for a Public Health Approach to Pelvic Floor Disorders Resulting from Pregnancy and Childbirth Trauma.International urogynecology journal · 2026Article
- Electrospun poly-4-hydroxybuterate scaffolds enable local zero-order estradiol delivery and promote collagen maturation in a hypoestrogenic rat model for pelvic organ prolapse repair.Biomaterials and biosystems · 2026Article
- Impact of childbirth mode and interaction of multiple factors on pelvic floor function: a comprehensive analysis of postpartum muscle strength indicators.Frontiers in global women's health · 2026Article
- The Correlation Between the Sensation of Vaginal Bulging and Anatomical POP-Q Stage in Estonia.International urogynecology journal · 2026Article
- Pelvic Organ Prolapse: Current Challenges and Future Perspectives.Journal of clinical medicine · 2025Review
- Efficacy of extracorporeal shock wave therapy for female stress urinary incontinence: a systematic review and meta-analysis.Translational andrology and urology · 2025Article
- International Delphi study of clinical and exercise professionals' opinion of physical activity prescreening and contraindications for participating in postpartum physical activity.British journal of sports medicine · 2025Article
- Impact of Lifestyle Modifications on the Prevention and Treatment of Pelvic Organ Prolapse.International urogynecology journal · 2025Review
- Voiding urodynamics parameters for women with and without symptomatic pelvic organ prolapse.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Review
- Commentary on "Pre- vs Post-operative Levator Ani Subtended Volume in Patients Undergoing Hysterectomy: A Comparative Imaging Study".International urogynecology journal · 2024Article
- Bidirectional Relationships between Sarcopenia and Pelvic Floor Disorders.International journal of environmental research and public health · 2024Review
Corrections and comments
- Commented on by
Authors and funding
23 authors at 15 institutions in 11 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThis manuscript is the International Urogynecology Consultation (IUC) on pelvic organ prolapse (POP) chapter one, committee three, on the Pathophysiology of Pelvic Organ Prolapse assessing genetics, pregnancy, labor and delivery, age and menopause and animal models. MATERIALS AND
methodsAn international group of urogynecologists and basic scientists performed comprehensive literature searches using pre-specified terms in selected biomedical databases to summarize the current knowledge on the pathophysiology of the development of POP, exploring specifically factors including (1) genetics, (2) pregnancy, labor and delivery, (3) age and menopause and (4) non-genetic animal models. This manuscript represents the summary of three systematic reviews with meta-analyses and one narrative review, to which a basic scientific comment on the current understanding of pathophysiologic mechanisms was added.
resultsThe original searches revealed over 15,000 manuscripts and abstracts which were screened, resulting in 202 manuscripts that were ultimately used. In the area of genetics the DNA polymorphisms rs2228480 at the ESR1 gene, rs12589592 at the FBLN5 gene, rs1036819 at the PGR gene and rs1800215 at the COL1A1 gene are significantly associated to POP. In the area of pregnancy, labor and delivery, the analysis confirmed a strong etiologic link between vaginal birth and symptoms of POP, with the first vaginal delivery (OR: 2.65; 95% CI: 1.81-3.88) and forceps delivery (OR: 2.51; 95% CI: 1.24-3.83) being the main determinants. Regarding age and menopause, only age was identified as a risk factor (OR : 1.102; 95% CI: 1.02-1.19) but current data do not identify postmenopausal status as being statistically associated with POP. In several animal models, there are measurable effects of pregnancy, delivery and iatrogenic menopause on the structure/function of vaginal support components, though not on the development of POP.
conclusionsGenetics, vaginal birth and age all have a strong etiologic link to the development of POP, to which other factors may add or protect against the risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.