Evidence map›Paper›PMID 35267041›Full record

ArticleThe Journal of infectious diseases2022

Ex Vivo Human and Porcine Skin Effectively Model Candida auris Colonization, Differentiating Robust and Poor Fungal Colonizers.

Emily F Eix, Chad J Johnson, Kayla M Wartman, John F Kernien, Jennifer J Meudt, Dhanansayan Shanmuganayagam, Angela L F Gibson, Jeniel E Nett

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Methods for skin load reduction of Candida auris: a systematic review.Antimicrobial resistance and infection control · 2026
    Pooled it
  2. Global characteristics and trends in research onFrontiers in microbiology · 2023
    Pooled it
  3. Review
  4. Diabetes and Immunosuppression Drive Distinct Patterns ofbioRxiv : the preprint server for biology · 2026
    Article
  5. Trk1 potassium transport is crucial for effectiveProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. mBio · 2026
    Article
  7. Article
  8. Journal of fungi (Basel, Switzerland) · 2026
    Review
  9. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  10. Article
  11. Review
  12. Microbiology spectrum · 2026
    Article
  13. StudyingPharmaceuticals (Basel, Switzerland) · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Dry Surface Biofilm Formation by Candida auris Facilitates Persistence and Tolerance to Sodium Hypochlorite.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Emily F EixDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Chad J JohnsonDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Kayla M WartmanDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
John F KernienDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Jennifer J MeudtDepartment of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Dhanansayan ShanmuganayagamDepartment of Animal and Dairy Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Angela L F GibsonDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0003-1181-7481
Jeniel E NettDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin–Madison · US

Funding

Mechanism(s) of pathogenicity for Candida aurisR01AI145939 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2020 to 2025
$2.7M
Characterizing Candida auris skin colonization and high-burden biofilm formationR21AI159583 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2021 to 2022
$427k
NIAID NIH HHS R01 AI145939NIAID NIH HHS R21 AI159583NIH HHS R01AI145939
6 · The paper itself

Abstract

Candida auris proliferates and persists on the skin of patients, often leading to health care-associated infections with high mortality. Here, we describe 2 clinically relevant skin models and show that C. auris grows similarly on human and porcine skin. Additionally, we demonstrate that other Candida spp., including those with phylogenetic similarity to C. auris, do not display high growth in the skin microenvironment. These studies highlight the utility of 2 ex vivo models of C. auris colonization that allow reproducible differentiation among Candida spp., which should be a useful tool for comparison of C. auris clinical isolates and genetically mutated strains.

Indexed as

CandidiasisAnimalsAntifungal AgentsCandidaCandida aurisHumansPhylogenySkinSwineAntifungal AgentsbiofilmCandidaCandida auriscolonizationex vivohumanmicroscopyporcineskin

Identifiers

PMID35267041
PMCPMC9113498
OpenAlexW4221096358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.