Evidence map›Paper›PMID 35266828›Full record

ArticleAntimicrobial agents and chemotherapy2022

Impact of Short-Term Storage on

Martin Okitwi, Stephen Orena, Katairo Thomas, Patrick K Tumwebaze, Oswald Byaruhanga, Samuel L Nsobya, Melissa D Conrad, Brett R Bayles, Philip J Rosenthal, Roland A Cooper

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Antimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Martin OkitwiInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Stephen OrenaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Katairo ThomasInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Patrick K TumwebazeInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Oswald ByaruhangaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Samuel L NsobyaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Melissa D ConradDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0002-9984-8030
Brett R BaylesDepartment of Natural Sciences and Mathematics, Dominican University of Californiagrid.255148.f, San Rafael, California, USA.
Philip J RosenthalDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0002-7953-7622
Roland A CooperDepartment of Natural Sciences and Mathematics, Dominican University of Californiagrid.255148.f, San Rafael, California, USA.ORCID 0000-0002-8437-9382
Infectious Diseases Research Collaboration · UGDominican University of California · USUniversity of California, San Francisco · US

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY, MOSES Robert KAMYA · 2010 to 2026
$29.3M
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3M
Resistance of Malaria Parasites to Artemisinin-Based Combination TherapiesR56AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2008 to 2008
$618k
NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI139179NIAID NIH HHS R56 AI075045NIAID NIH HHS U19 AI089674
6 · The paper itself

Abstract

We measured susceptibilities of Ugandan Plasmodium falciparum isolates assayed on the day of collection or after storage at 4°C. Samples were incubated with serial dilutions of 8 antimalarials, and susceptibilities were determined from 72-h growth inhibition assays. Storage was associated with decreased growth and lower 50% inhibitory concentration values, but differences between assays beginning on day 0 or after 1 or 2 days of storage were modest, indicating that short-term storage before drug susceptibility determination is feasible.

Indexed as

AntimalarialsMalaria, FalciparumDrug ResistanceHumansInhibitory Concentration 50Plasmodium falciparumUgandaAntimalarialsantimalarialscold storagedrug susceptibilityex vivogrowthmalariaPlasmodium falciparumUganda

Identifiers

PMID35266828
PMCPMC9017344
OpenAlexW4220745144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.