ArticleAntimicrobial agents and chemotherapy2022
An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
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In one paragraph
Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- In Vitro, In Silico, and In Vivo Evaluation of Antiplasmodial Activity of Ursodeoxycholic Acid Following GNPS Dereplication of an ActivePharmaceuticals (Basel, Switzerland) · 2026Article
- Lipid Composition of Nanocarriers Shapes Interactions of Cyclic Antimicrobial Peptide Gramicidin S with Their Membranes.International journal of molecular sciences · 2025Article
- Clinical challenges and technological breakthroughs in helminthic therapy for diabetes.Frontiers in immunology · 2025Review
- Revisiting theNPJ drug discovery · 2025Article
- Dobinin K Displays Antiplasmodial Activity through Disruption ofMolecules (Basel, Switzerland) · 2024Article
- Glucose-6-phosphate dehydrogenase and its 3D structures from crystallography and electron cryo-microscopy.Acta crystallographica. Section F, Structural biology communications · 2024Review
- Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle.International journal of molecular sciences · 2024Review
- Real-time measurements of ATP dynamics via ATeams inAntimicrobial agents and chemotherapy · 2024Article
- Fused Enzyme Glucose-6-Phosphate Dehydrogenase::6-Phosphogluconolactonase (G6PD::6PGL) as a Potential Drug Target inMicroorganisms · 2024Review
- Micromolar Dihydroartemisinin Concentrations Elicit Lipoperoxidation inAntioxidants (Basel, Switzerland) · 2023Article
- Structure ofInternational journal of molecular sciences · 2023Article
- Crystal structure of Leishmania donovani glucose 6-phosphate dehydrogenase reveals a unique N-terminal domain.Communications biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 3 countries.
Isabell Berneburg *Justus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Satyamaheshwar Peddibhotla *Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Kim C HeimschJustus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Kristina HaeusslerJustus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Patrick MaloneyConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Palak GosaliaConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Janina PreussJustus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Mahsa RahbariJustus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Oleksii SkorokhodDepartment of Life Sciences and Systems Biology, University of Torino, Turin, Italy.
Elena ValenteDepartment of Oncology, University of Torino, Turin, Italy.
Daniela UlliersDepartment of Oncology, University of Torino, Turin, Italy.
Luigi Felice SimulaDepartment of Clinical Chemistry, Ospedale Civile, Alghero, Italy.
Kathrin BuchholzJustus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Michael P HedrickConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Paul HershbergerConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Thomas D Y ChungConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Michael R JacksonConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Evelin SchwarzerDepartment of Oncology, University of Torino, Turin, Italy.
Stefan RahlfsJustus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Lars BodeUniversity of California, San Diegogrid.266100.3, La Jolla, California, USA.
Katja BeckerJustus Liebig University Giessen, Biochemistry and Molecular Biology, Interdisciplinary Research Center, Giessen, Germany.
Anthony B PinkertonConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.ORCID 0000-0003-4571-152X
Justus-Liebig-Universität Gießen · DESanford Burnham Prebys Medical Discovery Institute · USUniversity of Turin · ITUniversity of California San Diego · US
Funding
Sanford-Burnham Center for Chemical GenomicsU54HG005033 · NHGRI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI JACKSON, MICHAEL · 2008 to 2012
$72.5MSelective Inhibitors of Plasmodium Falciparum G6PD as Novel AntimalarialsR01AI104916 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BODE, LARS · 2014 to 2016
$1.2MNHGRI NIH HHS U54 HG005033NIAID NIH HHS R01 AI104916
Abstract
In
Indexed as
AntimalarialsGlucosephosphate Dehydrogenase DeficiencyMalariaMalaria, FalciparumMalaria, VivaxCarboxylic Ester HydrolasesGlucoseGlucosephosphate DehydrogenaseHumansHydrogen PeroxidePhosphatesPlasmodium falciparumPlasmodium vivax6-phosphogluconolactonaseAntimalarialsCarboxylic Ester HydrolasesGlucoseGlucosephosphate DehydrogenaseHydrogen PeroxidePhosphatesG6PDHinhibitorsmalariaPlasmodiumPlasmodium falciparumPlasmodium vivax
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.