ArticlemSystems2022
A Glyphosate-Based Herbicide Cross-Selects for Antibiotic Resistance Genes in Bacterioplankton Communities.
Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Insights into the dynamics of antibiotic resistance genes in the human gut microbiome across populations.Gut pathogens · 2026Article
- Impacts of pollution on the soil microbiome.Nature reviews. Microbiology · 2026Review
- Article
- Divergent mechanisms of active antibiotic resistance gene enrichment in soil driven by pesticide diversity.Nature communications · 2026Article
- How Glyphosate and Its Derivatives Influence Antimicrobial Resistance Emergence and Transmission: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2026Review
- Emerging Bacterial Resistance and Genotoxicity of Water-Soluble Fractions of Agricultural Soils from the Semiarid Region of Brazil Affected by the Continuous Use of Glyphosate.Bulletin of environmental contamination and toxicology · 2026Article
- Glyphosate-based herbicide exposure triggers genetic adaptation but not diversity collapse within bacterioplankton species.ISME communications · 2026Article
- Glyphosate resistance as a potential driver for the dissemination of multidrug-resistant clinical strains.Frontiers in microbiology · 2026Article
- Exploring the Ecological Impacts of Herbicides on Antibiotic Resistance Genes and Microbial Communities.Life (Basel, Switzerland) · 2025Article
- The effect of combinations of a glyphosate-based herbicide with various clinically used antibiotics on phenotypic traits of Gram-negative species from the ESKAPEE group.Scientific reports · 2024Article
- Non-Canonical Aspects of Antibiotics and Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Glyphosate as a Food Contaminant: Main Sources, Detection Levels, and Implications for Human and Public Health.Foods (Basel, Switzerland) · 2024Article
- Fighting Antimicrobial Resistance: Insights on How theJournal of chemical information and modeling · 2023Article
- An Insight into the Exploration of Antibiotic Resistance Genes in Calorie Restricted Diet Fed Mice.Nutrients · 2023Article
- Glyphosate affects persistence and tolerance but not antibiotic resistance.BMC microbiology · 2023Article
- Bacterial volatile organic compounds attenuate pathogen virulence via evolutionary trade-offs.The ISME journal · 2023Article
- Article
- Treatment with Glyphosate Induces Tolerance of Citrus Pathogens to Glyphosate and Fungicides but Not to 1,8-Cineole.Molecules (Basel, Switzerland) · 2022Article
- Glyphosate and glyphosate-based herbicides (GBHs) induce phenotypic imipenem resistance in Pseudomonas aeruginosa.Scientific reports · 2022Article
- Bioactive Nitrosylated and NitratedMolecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agrochemicals often contaminate freshwater bodies, affecting microbial communities that underlie aquatic food webs. For example, the herbicide glyphosate has the potential to indirectly select for antibiotic-resistant bacteria. Such cross-selection could occur if the same genes (encoding efflux pumps, for example) confer resistance to both glyphosate and antibiotics. To test for cross-resistance in natural aquatic bacterial communities, we added a glyphosate-based herbicide (GBH) to 1,000-liter mesocosms filled with water from a pristine lake. Over 57 days, we tracked changes in bacterial communities with shotgun metagenomic sequencing and annotated metagenome-assembled genomes (MAGs) for the presence of known antibiotic resistance genes (ARGs), plasmids, and resistance mutations in the enzyme targeted by glyphosate (enolpyruvyl-shikimate-3-phosphate synthase; EPSPS). We found that high doses of GBH significantly increased ARG frequency and selected for multidrug efflux pumps in particular. The relative abundance of MAGs after a high dose of GBH was predictable based on the number of ARGs in their genomes (17% of variation explained) and, to a lesser extent, by resistance mutations in EPSPS. Together, these results indicate that GBHs can cross-select for antibiotic resistance in natural freshwater bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.