SynthesisClinical psychology & psychotherapy2022
Deconstructing pathways to resilience: A systematic review of associations between psychosocial mechanisms and transdiagnostic adult mental health outcomes in the context of adverse childhood experiences.
Synthesis in Clinical psychology & psychotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of adverse childhood experiences in the development of post-traumatic stress disorder in adults over 18 years of age: a systematic review.BMC psychiatry · 2025Pooled it
- Deconstructing pathways to resilience: A systematic review of associations between psychosocial mechanisms and transdiagnostic adult mental health outcomes in the context of adverse childhood experiences.Clinical psychology & psychotherapy · 2022Pooled it
- Social contact recovery and depressive symptoms after the pandemic lockdowns: the lasting impact of child neglect.European journal of psychotraumatology · 2026Article
- Understanding how adverse childhood experiences influence the development of postpartum post-traumatic stress disorder: a qualitative study in China.European journal of psychotraumatology · 2026Article
- The CARE implementation study: scaling group-based psychoeducational trauma therapy across healthcare organizations in Canada.European journal of psychotraumatology · 2026Article
- The long-term impact of adverse childhood experiences on episodic memory in mid- to late-life among US older adults.Aging & mental health · 2026Article
- Maternal Adverse Childhood Experiences, Postpartum Care Utilisation, and Postpartum Depressive Symptoms.Paediatric and perinatal epidemiology · 2026Article
- Candidate transdiagnostic processes linking potentially traumatic experiences to psychopathology, mental well-being and resilience in emerging adults.BMC psychiatry · 2026Article
- Prenatal clinicians' perspectives on trauma-informed care competency and training.BMC medical education · 2026Article
- Development and Comparability of Internalizing and Externalizing Symptom Spectra From Adolescence to Young Adulthood.International journal of methods in psychiatric research · 2026Article
- Adverse childhood experiences, psychological distress, and the role of locus of control.Frontiers in epidemiology · 2026Article
- Causal relationship between inflammatory cytokines and posttraumatic stress disorder: a Mendelian randomization study and potential mechanism analysis.European journal of psychotraumatology · 2025Article
- Post-traumatic stress disorder in German youth: representative claims data pre- vs. intra-COVID-19-pandemic.European journal of psychotraumatology · 2025Article
- Adverse Childhood Experiences and Antenatal Depression: The Mediating Role of Social Support.Maternal and child health journal · 2025Article
- The Relationship Between Childhood Trauma and Mental Health in Indian Undergraduate Students: A Cross-sectional Study.Indian journal of psychological medicine · 2025Article
- Mechanisms of childhood trauma: an integrative review of a multimodal, transdiagnostic pathway.Neurobiology of stress · 2025Review
- Trauma and anxiety interactions relate to reward processing in adolescents.Journal of affective disorders · 2025Article
- Associations of Adverse and Positive Childhood Experiences with Transdiagnostic Risk Factors for Mental Health Problems in Black American Adults.Adversity and resilience science · 2025Article
- Cross-Sectional Analysis of Psychological Mediators Between Occupational Trauma and PTSD in Metropolitan Firefighters.European journal of investigation in health, psychology and education · 2025Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Adverse childhood experiences (ACEs) are identified with increased risk of adult mental health difficulties and negative impacts on well-being. However, there is a need to go beyond simple associations and identify candidate mechanisms underpinning the ACEs-mental health relationship. Further methodological heterogeneity points to issues around the operationalization of ACEs and the importance of modelling data using robust research designs. The aim of the current review was to synthesize studies that utilized formal mediation and/or moderation analyses to explore psychological and social variables on the pathway between clearly defined ACEs (as measured by the ACE questionnaire and Childhood Trauma Questionnaire [CTQ]) and common mental health outcomes (depressive, anxiety and post-traumatic stress disorder [PTSD] symptoms) across community samples aged over 18. A total of 31 papers were retrieved for critical appraisal. The majority of the studies explored factors mediating/moderating the link between child adversity and depression and less on anxiety and trauma. Most mechanisms were tested in only single studies, limiting the consistency of evidence. Evidence indicated that the mechanisms underlying associations between ACEs and adult mental health are likely to reflect multiple intervening variables. Further, there are substantial methodological limitations in the extant literature including the proliferation of causal inferences from cross-sectional designs and both measurement and conceptual issues in operationalizing adversity. Consistent transdiagnostic mechanisms relevant to common mental health problems were identified, including perceived social support, emotion regulation and negative cognitive appraisals/beliefs. Further research using longitudinal design is required to delineate the potential contribution of the identified mechanisms.
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