ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2022
A novel mouse model of hindlimb joint contracture with 3D-printed casts.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice.Nature communications · 2026Article
- Development of a novel external fixation device for inducing knee arthrofibrosis in rats.Scientific reports · 2026Article
- Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans.Cell reports. Medicine · 2026Article
- Tendon-Bone Interface Healing Improvement by Moderate Treadmill Exercise After Anterior Cruciate Ligament Reconstruction in a Murine Model.Orthopaedic journal of sports medicine · 2025Article
- Article
- Revealing gait as a murine biomarker of injury, disease, and age with multivariate statistics and machine learning.Scientific reports · 2025Article
- Soft Tissue Injury and Immobilization Are Both Required for Persistent Elbow Contracture in a Rat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Multivariate description of gait changes in a mouse model of peripheral nerve injury and trauma.PloS one · 2025Article
- A 3D-Printed Dummy for Training Distal Phalanx Amputation in Mice.Animals : an open access journal from MDPI · 2024Article
- Custom-made 3D-printed boot as a model of disuse-induced atrophy in murine skeletal muscle.PloS one · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Stiff joints formed after trauma, surgery or immobilization are frustrating for surgeons, therapists and patients alike. Unfortunately, the study of contracture is limited by available animal model systems, which focus on the utilization of larger mammals and joint trauma. Here we describe a novel mouse-based model system for the generation of joint contracture using 3D-printed clamshell casts. With this model system we are able to generate both reversible and irreversible contractures of the knee and ankle. Four- or 8-month-old female mice were casted for either 2 or 3 weeks before liberation. All groups formed measurable contractures of the knee and ankle. Younger mice immobilized for less time formed reversible contractures of the knee and ankle. We were able to generate irreversible contracture with either longer immobilization time or the utilization of older mice. The contracture formation translated into differences in gait, which were detectable using the DigiGait® analysis system. This novel model system provides a higher throughput, lower cost and more powerful tool in studying the molecular and cellular mechanisms considering the large existing pool of transgenic/knockout murine strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.