Evidence map›Paper›PMID 35266173›Full record

SynthesisClinical cardiology2022

Off-pump versus on-pump coronary artery bypass grafting for octogenarians: A meta-analysis involving 146 372 patients.

Lifu Sun, Meijing Zhou, Yumeng Ji, Xufeng Wang, Xiaowei Wang

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07118930 (Prospective Double-Blind Controlled Study of Sivelestat Sodium in the Perioperative Management of Off-Pump Coronary Artery Bypass Grafting), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07118930 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Prospective Double-Blind Controlled Study of Sivelestat Sodium in the Perioperative Management of Off-Pump Coronary Artery Bypass Grafting

TypeinterventionalSponsorAffiliated Hospital of Nantong UniversityRan2025 to 2027Enrolled62ConditionsCoronary Heart Disease, Coronary Artery Disease, Coronary Arterial Disease (CAD)ArmsSivelestat Sodium injection 2 h after OPCABG for 72 h, Saline (0.9% NaCl)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lifu SunDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0001-5254-2483
Meijing ZhouDepartment of Endocrine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-9811-5188
Yumeng JiDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-9345-0056
Xufeng WangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-6601-710X
Xiaowei WangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-4025-602X
Jiangsu Province Hospital · CNNanjing Medical University · CN

Funding

"333" Project of Jiangsu Province LGY2016006Medical Research Project of Jiangsu Health Commission ZDA2020004National Natural Science Foundation of China 81573234National Natural Science Foundation of China 81773445
6 · The paper itself

Abstract

There is an ongoing debate concerning the optimal surgical option of myocardial revascularization for octogenarians. The current meta-analysis aimed to compare clinical outcomes following off-pump coronary artery bypass grafting (OPCABG) or conventional coronary artery bypass grafting (CCABG) in octogenarians. PubMed, Cochrane, Web of Science, and EMBASE databases were searched to identify eligible studies from inception to March 2021. The analysis was performed using STATA 15.1. A literature search yielded 18 retrospective studies involving 146 372 patients (OPCABG = 44 522 vs. CCABG = 101 850). Pooled analysis showed a strong trend toward reducing mortality risk in the OPCABG group (odds ratio: 0.75, 95% confidence interval: 0.56-1.00, p = .05). However, it did not reach statistical significance. The sensitive analysis demonstrated that OPCABG was less likely to cause death than CCABG. There were comparable data in myocardial infarction, renal failure, deep sternal wound infection, and hospital stays between the two groups, although the incidence of stroke, atrial fibrillation, prolonged ventilation, and reoperation for bleeding was significantly lower in the OPCAGB group. OPCABG may be an effective surgical strategy for myocardial revascularization, especially in reducing the incidence of postoperative stroke, atrial fibrillation, prolonged ventilation, and reoperation for bleeding.

Indexed as

Atrial FibrillationStrokeAged, 80 and overCoronary Artery BypassHumansOctogenariansPostoperative ComplicationsRetrospective StudiesTreatment Outcomeatrial fibrillationearly mortalitymeta-analysisoctogenariansoff-pump coronary artery bypass graftingprolonged ventilationreoperation for bleedingstroke

Identifiers

PMID35266173
PMCPMC9019872
OpenAlexW4220723095

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.