Evidence map›Paper›PMID 35266128›Full record

ArticleJournal of general internal medicine2022

Association of Vaccination with the Persistence of Post-COVID Symptoms.

Juan P Wisnivesky, Usha Govindarajulu, Emilia Bagiella, Ruchir Goswami, Minal Kale, Kirk N Campbell, Kristin Meliambro, Zijian Chen, Judith A Aberg, Jenny J Lin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of general internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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  8. Interventions for Long COVID: A Narrative Review.Journal of general internal medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Juan P WisniveskyDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Usha GovindarajuluDepartment of Population Health and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emilia BagiellaDepartment of Population Health and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruchir GoswamiDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Minal KaleDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kirk N CampbellDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kristin MeliambroDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zijian ChenDivision of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Judith A AbergDivision of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jenny J LinDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jenny.lin@mssm.edu.ORCID 0000-0001-7104-8480
Icahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients who have had COVID-19 often report persistent symptoms after resolution of their acute illness. Recent reports suggest that vaccination may be associated with improvement in post-acute symptoms. We used data from a prospective cohort to assess differences in post-acute sequelae of COVID (PASC) among vaccinated vs. unvaccinated patients.

methodsWe used data from a cohort of COVID-19 patients enrolled into a prospective registry established at a tertiary care health system in New York City. Participants underwent a baseline evaluation before COVID-19 vaccines were available and were followed 6 months later. We compared unadjusted and propensity score-adjusted baseline to 6-month change for several PASC-related symptoms and measures: anosmia, respiratory (cough, dyspnea, phlegm, wheezing), depression, anxiety, post-traumatic stress disorder (PTSD; COVID-19-related and other trauma), and quality-of-life domains among participants who received vs. those who did not receive COVID-19 vaccination.

resultsThe study included 453 COVID-19 patients with PASC, of which 324 (72%) were vaccinated between the baseline and 6-month visit. Unadjusted analyses did not show significant differences in the baseline to 6-month change in anosmia, respiratory symptoms, depression, anxiety, PTSD, or quality of life (p > 0.05 for all comparisons) among vaccinated vs. unvaccinated patients. Similar results were found in propensity-adjusted comparisons and in secondary analyses based on the number of vaccine doses received.

conclusionsOur findings suggest that COVID vaccination is not associated with improvement in PASC. Additional studies are needed to better understand the mechanisms underlying PASC and to develop effective treatments.

Indexed as

COVID-19SARS-CoV-2AnosmiaCOVID-19 VaccinesDisease ProgressionHumansQuality of LifeVaccinationCOVID-19 VaccinesCOVID vaccinationlong COVIDpost-acute sequelae of COVIDsymptoms

Identifiers

PMID35266128
PMCPMC8906626
OpenAlexW4220732299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.