ArticleCardiovascular digital health journal2021
Circadian rhythm in critically ill patients: Insights from the eICU Database.
Article in Cardiovascular digital health journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07063303 (The Effect of Intermittent Feeding on Circadian Rhythm in Critical Illness), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Intermittent Feeding on Circadian Rhythm in Critical Illness
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap.Chest · 2026Guideline
- Quantifying sleep wake rhythms in the hospital environment with digital technologies.NPJ digital medicine · 2026Article
- Quantifying Sleep-Wake Rhythms in the Hospital Environment with Digital Technologies.medRxiv : the preprint server for health sciences · 2025Article
- Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death.Scientific reports · 2025Article
- Circadian rhythms in cardiovascular disease.European heart journal · 2025Review
- Association between atherogenic index of plasma and ICU 28-day mortality in geriatric diabetes: an EICU-based retrospective analysis.Lipids in health and disease · 2025Article
- Chrononutrition in Critical Illness.Nutrition reviews · 2025Review
- Natural Compounds that Modulate Circadian Rhythms.Current topics in medicinal chemistry · 2025Review
- Using routinely collected clinical data for circadian medicine: A review of opportunities and challenges.PLOS digital health · 2024Review
- Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- Are Short-Term Changes in Physiological Variables in ICU Patients as a Result of Physiotherapy of Any Clinical Relevance?Respiratory care · 2023Article
- Timing of diuretic administration effects on urine volume in hospitalized patients.Frontiers in physiology · 2023Article
- Sleep Assessment in Critically Ill Adults: Established Methods and Emerging Strategies.Critical care explorations · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the circadian variation among critically ill patients and its association with clinical characteristics and survival to hospital discharge in a large population of patients in the intensive care unit (ICU). Methods: Circadian variation was analyzed by fitting cosinor models to hourly blood pressure (BP) measurements in patients of the eICU Collaborative Research Database with an ICU length of stay of at least 3 days. We calculated the amplitude of the 24-hour circadian rhythm and time of the day when BP peaked. We determined the association between amplitude and time of peak BP and severity of illness, medications, mechanical intubation, and survival to hospital discharge. Results: Among 23,355 patients (mean age 65 years, 55% male), the mean amplitude of the 24-hour rhythm was 4.5 ± 3.1 mm Hg. Higher APACHE-IV scores, sepsis, organ dysfunction, and mechanical ventilation were associated with a lower amplitude and a shifted circadian rhythm ( Conclusion: The 24-hour rhythm is dampened and phase-shifted in sicker patients and those on mechanical ventilation, vasopressors, or inotropes. Dampening and phase shifting are associated with a longer length of stay and higher in-hospital mortality.
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Registered trials
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