Evidence map›Paper›PMID 35265784›Full record

ArticleJournal of the Endocrine Society2022

Human Placental Tissue Contains A Placental Lactogen-Derived Vasoinhibin.

Hülya Markl-Hahn, Leon Neugebauer, Livia Lenke, Sarah Ecker, Tamara Merz, Oscar McCook, Noura Khoder, Cosima Brucker, Peter Radermacher, Christiane Waller and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Hülya Markl-HahnInstitute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Leon NeugebauerInstitute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Livia LenkeInstitute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Sarah EckerDepartment of Psychosomatic Medicine and Psychotherapy, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Tamara MerzInstitute of Anesthesiological Pathophysiology and Process Engineering, University of Ulm, 89019 Ulm, Germany.
Oscar McCookInstitute of Anesthesiological Pathophysiology and Process Engineering, University of Ulm, 89019 Ulm, Germany.
Noura KhoderDepartment of Gynecology and Obstetrics, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Cosima BruckerDepartment of Gynecology and Obstetrics, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Peter RadermacherInstitute of Anesthesiological Pathophysiology and Process Engineering, University of Ulm, 89019 Ulm, Germany.
Christiane WallerDepartment of Psychosomatic Medicine and Psychotherapy, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Carmen ClappInstituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla , 76230 Juriquilla, Querétaro, México.ORCID https://orcid.org/0000-0002-7670-6718
Thomas BertschInstitute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.
Jakob TriebelInstitute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany.ORCID https://orcid.org/0000-0002-1989-8645
Nuremberg Hospital · DEUniversität Ulm · DEUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hormonal factors affecting the vascular adaptions of the uteroplacental unit in noncomplicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia (PE) were investigated for the presence of placental lactogen (PL)-derived, antiangiogenic vasoinhibin. Western blotting and mass spectrometry of placental tissue revealed the presence of a 9-kDa PL-derived vasoinhibin, the normal 22-kDa full-length PL, and a 28-kDa immunoreactive protein of undetermined nature. The sequence of the 9-kDa vasoinhibin includes the antiangiogenic determinant of vasoinhibin and could constitute a relevant factor in normal pregnancy and PE.

Indexed as

placentaplacental lactogenpreeclampsiavasoinhibin

Identifiers

PMID35265784
PMCPMC8900287
OpenAlexW4213183418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.