Evidence map›Paper›PMID 35265722›Full record

ArticleJournal of immunology research2022

Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses.

Wenzheng Chen, Yafei Chen, Li Liu, Yukang Wu, Pengcheng Fu, Yi Cao, Jianbo Xiong, Yi Tu, Zhengrong Li, Yi Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenzheng ChenDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, China.ORCID https://orcid.org/0000-0002-7890-7580
Yafei ChenSchool of Medicine, Southern University of Science and Technology, China.ORCID https://orcid.org/0000-0002-2500-7773
Li LiuMedical College of Nanchang University, China.ORCID https://orcid.org/0000-0003-3615-6712
Yukang WuMedical College of Nanchang University, China.ORCID https://orcid.org/0000-0001-8165-5428
Pengcheng FuMedical College of Nanchang University, China.ORCID https://orcid.org/0000-0003-0402-853X
Yi CaoDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, China.ORCID https://orcid.org/0000-0002-8262-5236
Jianbo XiongDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, China.ORCID https://orcid.org/0000-0003-2977-3798
Yi TuDepartment of Pathology, The First Affiliated Hospital of Nanchang University, China.ORCID https://orcid.org/0000-0003-1709-2688
Zhengrong LiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, China.ORCID https://orcid.org/0000-0001-7304-6729
Yi LiuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, China.ORCID https://orcid.org/0000-0002-2943-2144
Zhigang JieDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, China.ORCID https://orcid.org/0000-0002-6369-7306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a newly defined mode of programmed oxidative cell death. Knowledge of ferroptosis-related long noncoding (lnc) RNA in the tumor immune microenvironment of colon cancer is lacking. We systematically analyzed the correlations between ferroptosis-related lncRNAs and the tumor microenvironment, immune cell infiltration, and patient prognosis for 379 colon cancer samples in the Cancer Genome Atlas (TCGA). Using consensus clustering, we divided the 379 colon cancer patients into two subgroups (clusters 1 and 2) based on the differentially expressed ferroptosis-related lncRNAs. Cluster 1 was preferentially associated with longer overall survival, upregulated immune checkpoint inhibitor expressions, higher immunoscores, higher stromal scores, higher estimated scores, and distinct immune cell infiltration. Cancer- and metabolism-related pathways were enriched by gene set enrichment analyses. We constructed a prognostic signature of 15 ferroptosis-related lncRNAs (ZEB1-AS1, LINC01011, AC005261.3, LINC01063, LINC02381, ELFN1-AS1, AC009283.1, LINC02361, AC105219.1, AC002310.1, AL590483.1, MIR4435-2HG, NKILA, AC021054.1, and AL450326.1) and divided the patients into the high- and low-risk-score groups. The signature was validated using TCGA training and testing cohorts. The risk signature was an independent prognostic factor for predicting survival and excellently predicted the prognoses of patients with colon cancer. Moreover, the risk signature was related to immune characteristics. Chemosensitivity analyses showed that low-risk-score patients were more sensitive to sorafenib. In summary, our work revealed the important role of ferroptosis-related lncRNAs in the tumor microenvironment and immune cell infiltration and may help determine personalized prognoses and treatment for patients with colon cancer.

Indexed as

Colonic NeoplasmsFerroptosisRNA, Long NoncodingBiomarkers, TumorGene Expression Regulation, NeoplasticHumansPrognosisTumor MicroenvironmentBiomarkers, TumorRNA, Long Noncoding

Identifiers

PMID35265722
PMCPMC8898846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.